Frontiers and challenges of artificial enzyme and directed evolution

YU Yang; WANG Jiangyun

doi:10.3981/j.issn.1000-7857.2020.08.012

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Science & Technology Review ›› 2020, Vol. 38 ›› Issue (8) : 101-105. DOI: 10.3981/j.issn.1000-7857.2020.08.012

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Frontiers and challenges of artificial enzyme and directed evolution

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1. School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China;
2. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

Abstract

The directed evolution is a method to obtain proteins with desired traits by mimicking the evolution process at the molecular level in a lab environment. It is an important method for protein design and engineering. Apart from the engineering natural proteins, the directed evolution can be used to construct artificial enzymes by modifying the existing enzymes to have new catalytic activities. This paper reviews the recent studies of the industrial biocatalysis, the nanozyme design and the photocatalysis, as well as the challenges and the problems in the field of the directed evolution and the artificial enzyme.

Key words

artificial enzyme / directed evolution / industrial biocatalysis / nanozyme / photocatalysis

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YU Yang, WANG Jiangyun. Frontiers and challenges of artificial enzyme and directed evolution[J]. Science & Technology Review, 2020, 38(8): 101-105 https://doi.org/10.3981/j.issn.1000-7857.2020.08.012

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