This paper reviews potential issues faced when strategies such as HIV testing and surveillance, notification of HIV infected individuals and their sexual partners, knowledge level change and behavior intervention, health examine and certificates for sex workers, social management of HIV infected individuals being used in practices. We compares anonymous versus real name testing strategies, whether or not notifying spouse of HIV infected individuals, understanding the difference between knowledge change and behavioral change, whether or not control HIV by issuing health certificate for sex workers and putting all HIV infected individuals in one place. Sciences should be used in each of these prevention measures in order to be more effectively in reducing the AIDS epidemic.