L929 cells are used to study the effects of Magnetic Nano-Particles (MNPs) on cytotoxicity and evaluate the biological safety. MTT colorimetric assay was used to study the effects of different doses and durations of MNPs on the cells, and to evaluate the toxic effects of MNPs on cells and bio-safety. The results show that the leaching liquor with the MNPs modified with APTS is mainly of the first and the second grades well within the standard of cytotoxicity, but that of the MNPs modified by DMAB for 48h reaches the level of the fourth grade with a fair cytotoxicity. Compared with DMAB modified MNPs, the research in vitro reveals that the APTS modified MNPs have fewer inhibitions on the cell survival rate. Different doses and durations of MNPs see some differences in their effects on cytotoxicity, a certain dose may be found for MNPs with time-dependent lower inhibition of cell proliferation.
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