Abstract: Atmospheric low temperature plasmas, as a new emerging field, have recently received an increased attention through several novel applications, such as surface modifications of polymers, absorption and reflection of electromagnetic radiation, especially in the biomedical field with their outstanding advantages, such as the generation in atmospheric pressure, low gas temperature, and high activity. The plasma jet devices generate plasma plumes in open space (surrounding air) rather than only in confined discharge gaps. Thus, they can be used for direct treatments with no limitation on the size of the object to be treated. Atmospheric pressure plasma jet devices driven by DC source, AC source, RF source, microwave and pulsed-DC source are reviewed in this paper, as well as their physical characteristics, the effect of inactivating microorganisms, and their biomedical applications. Finally, the problems existing in generating atmospheric low temperature plasma jet, the possible solutions, and the prospect of their application fields in the future are discussed.