|
|
Effects of Uyghur Medicine Munziq on the Myocardial Ischemiareperfusion Injury of Rats with the Abnormal Savda Syndrome |
MAIMAITIAILI Abudunaibi1, ABUDUREHEMAN Mulati1, SHABITI Aisikaer1, AIBIBULA Aili1, UPUR Halmurat2 |
1. The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;
2. Faculty of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi 830011, China |
|
|
Abstract: This paper aims to investigate the effects of different doses of abnormal Savda Munziq on myocardial ischemia-reperfusion injury (MI/RI) in rats with the abnormal Savda syndrome. Seventy-two rats with abnormal Savda syndrome and 24 healthy ones were selected and divided into eight groups: ischemia-reperfusion model group, high dose maturation agent group, middle dose group mature agent, small doses of maturation agent group, normal ischemia-reperfusion group, model sham group and atorvastatin intervention group (positive control group). Each group contained 12 rats. The enzyme-linked immunosorbent assay (ELISA) was used to detect the serum myocardial enzyme and troponin levels, and hematoxylin and eosin (HE) staining was used to observe changes of the myocardial tissues in the different groups. The results showed that in the Munziq intervention groups, the serum creatine kinase and troponin levels were significantly lower than those in the model group, and the middle-dose group showed the lowest levels. The HE staining of myocardial tissue showed that the myocardial edema and muscle fiber proliferation levels were significantly higher in the Munziq intervention groups than in the model ischemia-reperfusion injury group, and the middle-dose group showed the least cardiac tissue damage. Moderate to high doses of abnormal Savda Munziq may be more effective on abnormal Savda ischemia-reperfusion injury in rats than atorvastatin, but further studies are still needed to confirm the conclusion.
|
Received: 21 April 2014
|
|
|
|
|
[1] Schulze C J, Wang W, Kumari R, et al. Imbalance between tissue inhibitor of metalloproteinase-4 and matrix metalloproteinase during acute myocardial [correction of myocardial] ischemia-reperfusion injury[J]. Circulation, 2007, 107(19): 2487-2492.
[2] Tomas F, Robert W, Pavel P. Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: A randomised controlled trial 2010[J]. Interact Cardio Vascular Thorac Surgery, 2010, 78(11): 758-762.
[3] Werner M, Kazuo K, Hirofumi K. Myocardial protection via the coronary sinus long-term effects of intermittent coronary sinus occlusion as an adjunct to reperfusion in acute myocardial infarction[J]. Circulation Journal, 2008, 104(72): 526-533.
[4] Lum H, Roebuck K A. Oxidant stress and endothelial cell dysfunction[J]. America Journal of Physiology: Cell Physiology, 2005, 280(4): C719-C741.
[5] Hoffman J W, Gilbert T B, Poston R S, et al. Myocardial reperfusion injury: Etiology, mechanisms, and therapies[J]. Extra Corporal Technology, 2007, 36(4): 391-411.
[6] RuizGines J A, LopezOngil S, Gonzalez R M, et al. Reactive oxygen species induce proliferation of bovine aortic endothelial cells[J]. Cardiovascular Pharmacology, 2006, 35(1): 109-113.
[7] 哈木拉提·吾甫尔. 异常黑胆质新论[M]. 乌鲁木齐: 新疆科学技术出版 社, 2008: 54. Upur Halmurat. Modern research of abnormal Savda syndrome theory[M]. Urumq: Xinjiang Science Technology Publishing Company, 2008: 54.
[8] Murat K, Ruxandra P, Upur H. Towards modernization of the formulation of the traditional Uighur medicine herbal preparation abnormal Savda Munziq[J]. Evidence-based Complementary and Alternative Medicine, 2012, doi: 10.1155/2012/863101.
[9] Yusup A, Upur H, Umar A, et al. Abnormal Savda Munziq, an herbal preparation of traditional Uighur medicine, may prevent 1, 2-dimethyl hydrazine-induced rat colon carcinogenesis[J]. Evidence-based Complementary and Alternative Medicine, 2011, doi: 10.1093/ecam/ nep059.
[10] Yusup A, Upur H, Umar A, et al. Protective effeets of Munziq and Mushil of abnormal Savda to mitoehondrial oxidative damage[J]. Fundamtal & Clinical Pharmacology, 2004, 18(4): 471-476.
[11] Yusup A, Upur H, Umar A, et al. Ethanol extract of abnormal Savda Munziq, a herbal preparation of traditional uighurmedicine, inhibits caco-2 cells proliferation via cell cycle arrest and apoptosis[J]. Evidence-Based Complementary and Alternative Medicine, 2012, 92 (63): 29-36.
[12] 哈木拉提·吾甫尔, 阿依努尔·买提斯迪克, 努尔买买提·艾买提, 等. 异常黑胆质证载体动物模型的建立及其自然恢复反证[J]. 新疆医科 大学学报, 2006, 29(10): 910-914. Upur Halmurat, Maimaitisidike Aynur, Amat Nurmammat, et al. Establishment of an animal model of abnormal Savda and the natural restoration of a rebuttal[J]. Journal of Xinjiang Medical University, 2006, 29(10): 910-914.
[13] 阿依努尔·买提斯迪克, 胡汉华, 哈木拉提·吾甫尔, 等. 异常黑胆质 载体动物模型支配器官组织细胞超微结构观察[J]. 新疆医科大学学 报, 2006, 29(10): 919-921. Maimaitisidike Aynur, Hu Hanhua, Upur Halmurat, et al. Abnormal Savda syndrome model and its ultrastructureal observation of dominationg organs[J]. Journal of Xinjiang Medical University, 2006, 29 (10): 919-921.
[14] 张莉, 哈木拉提·吾甫尔, 胡尔西旦·尼可孜, 等. 异常黑胆质载体动 物肿瘤模型的建立及其神经内分泌免疫指标的改变[J]. 国际病理科 学与临床杂志, 2007, 27(5): 376-381. Zhang Li, Upur Halmurat, Niyazi Huerxidan, et al. Establishment of abnormal Savda syndrome tumor model and the alteration of its neuroendocrine-immune network[J]. International Journal of Pathology and Clinical Medicine, 2007, 27(5): 376-381.
[15] Kaufman R J. Orchestrating the unfolded protein response in health and disease[J]. Journal of Clinical Investigation, 2012, 110(10): 1389-1398.
[16] Snoeckx L H, Comelussen R N, Van Nieuwenhoven F A, et al. Heat shock proteins and cardiovascular pathophysiology[J]. Physiology Review, 2001, 81(4): l461-1497.
[17] Shintani-IshidaK,NakajimaM,UemuraK,etal.Ischemicpreconditioning protects cardiomyocytes againstischemic injury by inducing GRP78[J]. Biochemic Biophysical Reserch and Communication, 2006, 345(4): 1600-1605.
[18] Upur H, Yusup A, Baudrimont I, et al. Inhibition of cell growth and cellular protein, DNA and RNA Synthesis in human hepatoma (HepG2) cells by ethanol extract of abnormal Savda Munziq of traditional Uighur medicine[J]. Evidence-Based Complementary and Alternative Medicine, 2011, 25(14): 24-29. |
[1] |
WUSHUER Palidan, HIZBILLA Mawlanjan, AMAT Nurmuhammat, UPUR Halmurat. Serum Metabonomic Study of Alzheimer's Disease Rat Models with Abnormal Savda Syndrome[J]. journal1, 2014, 32(28/29): 39-47. |
[2] |
ANAYTUL Mihrigul, TAX Ayxam, HUJABDU Halida, UPUR Halmurat, AMAT Nurmamat. Effect of Uighur Medicine Abnormal Savda Munziq on Pathological Morphologyof Breast Tissueand theLevel of Serum Sex Hormonesin the Model of Galactophore Hyperplasia[J]. journal1, 2014, 32(26): 79-84. |
[3] |
MAMTIMIN Batur, SUN Feng, KELIMU Alimujiang, KONG Bin, GONG Can, UPUR Halmurat. Correlation Analysis of Plasma Fatty Acid Levels in Patients with Tumor and Abnormal Savda in Uyghur Medicine[J]. journal1, 2014, 32(18): 62-66. |
[4] |
TUERXUN Kelibiena, SIMAYI Mihereguli, WUFUE Dilinuer, AIZEZI Renaguli, UPUR Halmurat. Prethrombotic Seate in Bronchial Asthmatic Patients with Abnormal Savda[J]. journal1, 2014, 32(17): 64-70. |
[5] |
MAMTIMIN Batur, XU Weifang, LI Wei, WU Yan, UPUR Halmurat. Comparative Study of Stasis-Phlegm and Abnormal Savda Syndrome Asthma Patients Based on NMR[J]. journal1, 2014, 32(16): 24-28. |
[6] |
WANG Yanjiao, UPUR Halmurat, MAMATIMIN Imam, HELIM Resalat, ABDURIYIM Ayupjan, BAKRI Iskandar. A Rat Model of Hepatocarcinoma Carrying Abnormal Savda and Its Morphological Study[J]. journal1, 2014, 32(14): 74-78. |
|
|
|
|