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| Functionalization of Multi-walled Carbon Nanotubes for Sustained-releasing Ofloxacin |
| LI Sanqing1, LIU Yaochi2, YU Jingang2 |
| 1. Infectious Diseases Department, the PLA 425 Hospital, Sanya 572000, Hainan Province, China;2. College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China |
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Abstract: As the third generation of synthetic flouroquinolone antibacterials, the ofloxacin is a potent antifungal agent with a broad antifungal spectrum, a strong antibacterial activity, the ability of completely oral absorption,a wide distribution in tissue and a high bioavailability. By using the nitric acid to treat multi-walled carbon nanotubes (MWNTs) under the microwave irradiation, the carboxyl groups were introduced onto the MWNTs and the oxidized MWNTs (MWNTs-COOH) were prepared. Catalized by the p-toluenesulfonic acid, the poly(ethylene glycol) modified MWNTs (PEG-g-MWNTs) with good dispersivity were synthesized. The PEG-g-MWNTs composites were used as the drug delivery for drug loading/releasing of the ofloxacin. It is indicated that the PEG-g-MWNTs has a great load rate (92.8%) for the ofloxacin, which can be sustained, controlled and released in the phosphate buffer solution (pH=7.4) in 24h.
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Received: 05 January 2013
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| [1] |
YAO Yuanxiang, LIU Jinyun, TAN Xinliang, PENG Zhiguang, JIN Hangdan. Effects of Various Solvent Systems and the Ratios on Thin-Layer Chromatographic Enantio-separation of Propranolol Hydrochloride[J]. journal1, 2014, 32(1): 65-69. |
| [2] |
MA Xia;WU Yanli;YU Hongqian. Application of β-Poly-Malic Acid/Chitosan in the Preparation of Essence Microcapsule[J]. , 2013, 31(4): 54-59. |
| [3] |
LI Sanqing;LIU Yaochi;YU Jingang;. Interaction of Hydroxypropyl-β-cyclodextrin Modified Multi-walled Carbon Nanotubes and Mandelic Acid[J]. , 2013, 31(11): 60-64. |
| [4] |
. Research Advances of Carbon Nanotube-based Gas Sensors[J]. , 2009, 27(0921): 107-110. |
| [5] |
. Effects of PEG Concentration and Temperature on the Rheological and Thermodynamic Properties of PSF Casting Solution[J]. , 2009, 27(0918): 71-74. |
| [6] |
. Synthesis of Polylactic Acid-Polyethylene Glycol via Melt Copolymerization[J]. , 2009, 27(0913): 7-8. |
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2013, Vol. 31 
