异常黑胆质型肝癌病证模型肝脏形态学研究

doi:10.3981/j.issn.1000-7857.2014.14.012

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Abstract: The effect of abnormal savda on the initiation and development of hepatocarcinoma was studied by establishing a rat model of hepatocarcinoma carrying abnormal savda. A rat model with abnormal savda disease was first established, and diethylnirtosamine (DEN) was used to further establish a model of hepatocarcinoma carrying abnormal savda under Uighur medicine treatment. The morphology and pathological changes of the liver were observed at the 11th, 15th and 20th week. After the 20th week, cancerization was induced both in the experimental group (hepatocarcinoma with abnormal savda) and the model control group (without abnormal savda syndrome but DEN treatment), but the pathological changes of the liver surface in the experimental group appeared faster than those in the model control group, and the incidence of hepatocellular carcinoma (100%) of the former was significantly higher than that of the latter (72%) (P<0.01). These findings indicate that abnormal savda hilit facilitates transformation of hepatocyte to hepatocellular carcinoma.

Key words： Uighur medicine abnormal savda hilit DEN hepatocarcinoma

Received: 16 December 2013

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http://www.kjdb.org/EN/10.3981/j.issn.1000-7857.2014.14.012 OR http://www.kjdb.org/EN/Y2014/V32/I14/74

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