维药异常黑胆质成熟剂对异常黑胆质大鼠心肌缺血再灌注损伤的影响

doi:10.3981/j.issn.1000-7857.2014.23.009

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Abstract: This paper aims to investigate the effects of different doses of abnormal Savda Munziq on myocardial ischemia-reperfusion injury (MI/RI) in rats with the abnormal Savda syndrome. Seventy-two rats with abnormal Savda syndrome and 24 healthy ones were selected and divided into eight groups: ischemia-reperfusion model group, high dose maturation agent group, middle dose group mature agent, small doses of maturation agent group, normal ischemia-reperfusion group, model sham group and atorvastatin intervention group (positive control group). Each group contained 12 rats. The enzyme-linked immunosorbent assay (ELISA) was used to detect the serum myocardial enzyme and troponin levels, and hematoxylin and eosin (HE) staining was used to observe changes of the myocardial tissues in the different groups. The results showed that in the Munziq intervention groups, the serum creatine kinase and troponin levels were significantly lower than those in the model group, and the middle-dose group showed the lowest levels. The HE staining of myocardial tissue showed that the myocardial edema and muscle fiber proliferation levels were significantly higher in the Munziq intervention groups than in the model ischemia-reperfusion injury group, and the middle-dose group showed the least cardiac tissue damage. Moderate to high doses of abnormal Savda Munziq may be more effective on abnormal Savda ischemia-reperfusion injury in rats than atorvastatin, but further studies are still needed to confirm the conclusion.

Key words： Munziq abnormal Savda syndrome rats ischemia-reperfusion injury

Received: 21 April 2014

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http://www.kjdb.org/EN/10.3981/j.issn.1000-7857.2014.23.009 OR http://www.kjdb.org/EN/Y2014/V32/I23/62

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