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Modulation of Apoptotic Effects in Host Cells During Mycobacterial Tuberculosis Infection |
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Abstract: Tuberculosis, one of the major infectious diseases worldwide, is caused by Mycobacterium Tuberculosis (MTB) infection. There are around one-third of the world's population is latently infected. In recent years, the tuberculosis control situation is even grimmer along with the multi-drug resistant MTB and HIV epidemic. MTB is a highly adapted human pathogen that has evolved with multiple strategies in its attempt to avoid an efficient host immune response. Apoptosis is an ancient immune defense response to intracellular pathogens in both plant and animal kingdoms. This paper reviews the current progresses in the field of interaction between mycobacteria and host cells regarding the induction of host cell death by apoptosis. It is believed that MTB can modulate macrophage apoptosis through a variety of ways, by either inducing or inhibiting apoptosis after infection. However, the molecular mechanisms of host cell apoptosis induction or inhibition are still not well understood. Therefore, the identification of apoptosis-related genes in the genome of MTB is necessary to investigate the details of this host-pathogen interaction and may be useful for the development of new drug targets and/or vaccine candidates.
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Received: 09 October 2009
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