苯乙烯衍生物的γ－酮腈等系列双官能团化反应研究

doi:10.3981/j.issn.1000-7857.2022.20.012

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Abstract: The bifunctional reaction of styrene derivatives with alcohols, ketones, nitriles, ethers, thioethers and other solvent molecules is a radical relay reaction discovered and developed by Wang Naixing's research group since 2012. A persistent and stable radical (free radical on the carbon atom adjacent to the benzene ring) is generated during the reaction duo to the p-π conjugation effect of the benzene ring, this reaction is called thes Wang reaction since 2018. This effective reaction can realize the high value conversion of the styrene derivatives through one-step reaction, which is of great significance for the new synthesis methods of drugs and intermediates.

Key words： bifunctional reaction radical relay reaction p-&pi conjugation effect synthesis methods

Received: 20 July 2022

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Cite this article:

Wang Naixing. The bifunctionalization reactions with series γ-ketone nitrile of styrene derivatives[J]. Science & Technology Review, 2022, 40(20): 101-110.

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http://www.kjdb.org/EN/10.3981/j.issn.1000-7857.2022.20.012 OR http://www.kjdb.org/EN/Y2022/V40/I20/101

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