|
|
Application of Yunnan Baiyao Baoxianzi in emergency treatment of severe traumatic hemorrhage |
LI Ran1, FU Chao2, LIU Yang3, LIU Mingfa2 |
1. Cardiac Surgery Department of Hohhot First Hospital, Hohhot 010030, China;
2. Emergency Medicine Department of Hohhot First Hospital, Hohhot 010030, China;
3. UItrasonic Diagnosis Department of Hohhot First Hospital, Hohhot 010030, China |
|
|
Abstract: Traumatic hemorrhage is an important challenge in the field of first aid and may cause imbalance of the coagulationanticoagulation system. Yunnan Baiyao Baoxianzi is a classic first-aid medicine in the treatment of traumatic hemorrhage in traditional Chinese medicine. It has the effects of both hemostasis and anticoagulation. In this study, orthopaedic trauma patients at the emergency center of Hohhot First Hospital from Jan 2018 to Dec 2021 were taken as the research objects. Through a prospective parallel controlled clinical study, the hemostatic efficacy of baozi was systematically evaluated in terms of intraoperative blood loss, postoperative drainage, hemoglobin decline, prothrombin time (PT), activated partial prothrombin time, fibrinogen (FBG), blood transfusion rate, prognosis of bleeding/coagulation adverse reactions, etc. The results showed that the intraoperative bleeding volume, postoperative drainage volume, hemoglobin decline, blood transfusion rate, PT, and prognosis of bleeding/coagulation adverse reactions in the Baoxianzi group (n=27) were significantly lower than those in the control group (n= 24) and the FBG in the Baoxianzi group was significantly higher than that in the control group. Thus, Baoxianzi can maintain the balance of coagulation-anticoagulation system, significantly reduce bleeding volume and benefit anticoagulation at the same time, preventing TIC and reducing adverse prognosis reactions.
|
Received: 03 June 2022
|
|
|
|
[1] 徐鹏陶,吴兴,张玲,等.氨甲环酸对创伤性凝血病患者凝血功能指标与炎症因子水平的影响[J].当代医学, 2018, 24(17):36-38.
[2] Hadi K, Shahram P, Mohammad K H, et al. Overview of agents used for emergency hemostasis[J]. Trauma Monthly, 2016, 21(1):1-8.
[3] 金慧,万鹏,彭娜,等.凝血和血小板功能监测仪在创伤性凝血病早期诊断中的应用评价[J].中国急救复苏与灾害医学杂志, 2014(8):696-701.
[4] 沈哲源,田书委,孔宇,等.创伤性凝血病发病机制及诊治研究进展[J].中华创伤杂志, 2018, 34(4):377-384.
[5] 邱文奎,徐伟,栗磊,等.云南白药对老年股骨转子间骨折股骨近端防旋髓内针内固定术围手术期隐性失血、术后髋关节活动的影响[J].陕西中医, 2019, 40(6):773-776.
[6] 卢祺炯,夏丽娟,闫俊岭,等.云南白药的一般药理学研究[J].中华中医药学刊, 2014, 32(8):1879-1881.
[7] Wafaisade A, Lefering R, Maegele M, et al. Coagulation management of bleeding trauma patients is changing in German trauma centers:An analysis from the trauma registry of the German Society for Trauma Surgery[J]. Journal of Trauma and Acute Care Surgery, 2012, 72(4):936-942.
[8] 梅程清,叶正龙,邹晖,等.多发伤患者创伤性凝血病影响因素分析[J].中国医刊, 2017, 52(12):85-88.
[9] 张锦鑫,李俊杰,花蕾,等.创伤性凝血病发病机制的研究进展[J].国际外科学杂志, 2015, 42(2):142-144.
[10] 陈国枢,陈立,王涛,等.急诊车祸多发伤并发创伤性凝血病的相关因素分析[J].广东医学, 2016, 37(7):1016-1018.
[11] 胡柏生,王毅鑫,鲁宇飞,等.急性创伤性凝血病的诊疗进展[J].医学研究杂志, 2016, 45(10):165-167.
[12] 邢国宽,刘喜凤,苑佳琦,等.氨甲环酸与利伐沙班联合应用对膝关节置换术中减少出血及预防静脉血栓的临床研究[J].实用药物与临床, 2016, 19(3):326-330.
[13] 黄剑吟,封启明.急性创伤性凝血病发病机制的研究进展[J].海南医学, 2015, 26(21):3190-3194.
[14] 杨宁强,尚攀峰,葛华.非那雄胺减少前列腺电切术中出血的研究[J].中华临床医师杂志(电子版), 2013, 7(24):11318-11320.
[15] 张小梅,莫治强,李俊明,等.云南白药对围手术期血小板表面糖蛋白及超微结构影响的研究[J].昆明医学院学报, 2004(2):56-59.
[16] 马新建,高慎元,叶坤,等.云南白药保险子联合非那雄胺在前列腺电切术围手术期应用的临床研究[J].临床医药文献电子杂志, 2017, 4(71):13995-13996.
[17] 李增磊,包杰,何桂芳.云南白药胶囊对创伤性骨折患者术中出血量的影响[J].内蒙古中医药, 2021, 40(3):50-51.
[18] 孔祥涛.云南白药联合氨甲环酸对胸腰椎骨折手术患者隐性失血量和凝血功能的影响[J].辽宁医学杂志, 2021, 35(2):29-32.
[19] 李钦柱.中西医结合治疗创伤性骨折91例[J].河南中医, 2016, 36(7):1220-1222.
[20] 王鑫,李文文,宋佳格,等.浅析调气治血之三七配伍治疗血证[J].中医药通报, 2017, 16(1):44-45.
[21] 刘正君,吉延慧,张琪嘉钰,等.三七止血作用的实验研究[J].陕西中医学院学报, 2015, 38(2):71-73.
[22] Huang L F, Shi H L, Gao B, et al. Decichine enhances hemostasis of activated platelets via AMPA receptors[J]. Thrombosis Research, 2014, 133(5):848-854.
[23] 苏雅,赵益桂.三七三醇皂甙对动物血小板功能及血栓形成的影响[J].中草药, 1996, 27(11):666-668. |
[1] |
XU Xiaolong, ZHANG Mina, LI Zhenxuan, LIU Qingquan. The significance of coagulation dysfunction in the formation and treatment of cardiac function injury in sepsis[J]. Science & Technology Review, 2022, 40(23): 49-57. |
[2] |
TUERXUN Kelibiena, SIMAYI Mihereguli, WUFUE Dilinuer, AIZEZI Renaguli, UPUR Halmurat. Prethrombotic Seate in Bronchial Asthmatic Patients with Abnormal Savda[J]. journal1, 2014, 32(17): 64-70. |
[3] |
LI Zhiyong;PEI Xuan. Theoretical and Numerical Analyses of Fatigue Crack Growth and Rupture of Diseased Vessel[J]. , 2012, 30(34): 28-31. |
[4] |
MAITISIDIKE Ayinuer;ABUDULAIHAITI Wuerguli;UPOR Hamulati;AIMAITI Nuermaimaiti;MUSHA Halida;AIZEZI Renaguli. Hemorheological Effects of Abnormal Savda Munziq, as a Traditional Uighur Medicine, on the Abnormal Savda Rat Model[J]. , 2011, 29(27): 31-35. |
[5] |
AIZEZI Renaguli;WUSHUER Palidan;ABUDOUREYIMU Shajidan;JIN Wei;UPUR Halmurat. Relationship Between Changes of Prethrombotic State with Coronary Heart Diseases and Traditional Urgur Medicine Syndromes[J]. , 2011, 29(24): 42-46. |
|
|
|
|