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Abstract: To investigate the correlation between serum uric acid and related indexes of glucose metabolism, 301 blood samples were collected from a hospital, among which 149 are from hyperuricemia patients as the hyperuricemia group and 152 are from healthy subjects as the control group. The height, weight, DBP, SBP and waist circumference of both groups were recorded and SUA, TG, TC, HDL, LDL, FPG and FINS were determined. The FINS was measured with radioimmunoassy (RIA). The HOMA-IR was calculated based on FPG and FINS with the minimal model. The statistical data were analyzed by SPSS 16.0 software. Results show that for the hyperuricemia group, as compared with the control group, the FINS levels are increased significantly ((27.85±19.56)μIU/mL vs (18.38±10.33)μIU/mL, P<0.01), the HOMA-IR is significantly higher ((8.38±7.96) vs (4.08±2.44), P<0.01), the HbA1c levels and FPG levels are also significantly increased ((6.29%±1.81%) vs (4.94%±0.43%), P<0.01), ((6.38±2.68)mmol/L vs (4.96±0.56)mmol/L , P<0.01). The multiple stepwise regression analysis shows that the SUA levels are related to BMI, HbA1c, TG and HDL, a positive correlation between SUA levels and TG (r=0.321, P<0.01), FPG (r=0.207, P<0.01), HbA1c(r=0.353, P<0.01), INS(r=0.337, P<0.01), HOMA-IR (r=0.315, P<0.01), but a negative correlation with HDL in two groups. It is concluded that hyperuricemia is correlated with abnormal blood glucose levels and the insulin resistance.
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Received: 13 October 2009
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2010, Vol. 28 
