Abstract: Based on the geological condition, surrounding environment and engineering characteristics of the river-crossing tunnel along the South Tibet Road in Shanghai, this paper analyzes the construction difficulties and potential risks, which involve many factors: complicated geological conditions, variable soil thickness, crossing of the Huangpu River and metro M8, the curved excavations. The related technologies were studied, concerning the large slurry balance shield for excavating river-crossing tunnel and traversing operational tunnels under conditions of practical construction. The results indicate that it is possible to prevent leaking of slurry, keep slurry balance on the excavation face and control the settlement of operational tunnels by controlling pressure and volume of slurry in real-time and keeping an appropriate speed of excavation. The coordinative platform is composed of the guidance system and the information management system for information to be integrated and shared, which improves automation and effective management level of shield construction. The technologies of designing and producing large slurry balance shield can also be used for similar constructions in future.