The abruption and modality rate of cancer is growing every year in the world. And the therapeutic means are far from a thorough heal of the disease. Both the causes of the disease and the mechanisms underlying its metastasis are still under investigation. Hyperthermic treatment can cause complete and selective destruction of malignant cells. To understand how heat affects tumor, entropy is used to characterize the structure or the assemble degree of a living system in thermal dynamics. The flow of entropy between tumor and normal cells from the reference point of entropy is calculated. Entropy flows resulting from external energy (heat), diffusion current, chemical reaction rate and velocity gradient coupled with viscous stress, are analyzed both quantitatively and qualitatively. The results show that the long-term hyperthermia environment can increase the positive entropy of the system and finally inhabit the growth of tumor. The analysis provides a new method for study of the relationship between the tumor growth and the environment, and a possible alternative cancer treatment.