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MOLECULAR CHARACTERIZATION OF EXTREME ENZYMES ISOLATED FROM MARINE EXTREMOPHILES |
WANG Tian-hong, HOU Yun-hua |
State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China |
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Abstract: Enzymes from extremophiles (extremozymes) show activity and stability at extremes of temperature, pH value, low water activity and high hydrostatic pressure. Thus, extremozymes have potential applications in biological catalysis and biotransformation. The discovery of the new extremophies, the sequencing of the genomes and the development of gene engineering technology have expedited the discovery and preparation of the novel enzymes. The enzymatic activity and specificity of the extreme enzymes have further been improved by protein engineering and directed evolution, which accelerates the industrial application of the extreme enzymes. Research on the extreme enzymes not only have enhanced our understanding of the have enzymes but also enriched the theory of molecular evolution.
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Received: 01 January 1900
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