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| Hemorheological Effects of Abnormal Savda Munziq, as a Traditional Uighur Medicine, on the Abnormal Savda Rat Model |
| MAITISIDIKE Ayinuer1, ABUDULAIHAITI Wuerguli1, UPOR Hamulati1, AIMAITI Nuermaimaiti1, MUSHA Halida2, AIZEZI Renaguli1 |
| 1. Traditional Uighur Medicine Department, Xinjiang Medical University, Urumqi 830011, China;2. Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China |
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Abstract: The hemorheological and coagulation effects of Abnormal Savda Munziq (ASM), as an herbal preparation used in Traditional Uighur Medicine, on the abnormal savda rat model are investigated. The level of whole blood viscosity, plasma viscosity, whole blood reduced viscosity, erythrocyte aggregation index, deformation index, rigidity index, electrophoresis index, hematocrit, and other indicators were determined by the LBY-N6B instrument. The level of PT, FIB, TT, and APTT were measured by automated blood coagulation analyzer. The results are as follows: (1) Compared with control group, the whole blood viscosity (low, moderate, and higher shear rate), plasma viscosity are significantly higher in the model group (P<0.05); The erythrocyte rigidity index and erythrocyte deformability index decrease significantly (P<0.05); The thrombin time shortens and FIB increases significantly (P<0.01 respectively); The erythrocyte aggregation index difference is not remarkable (P>0.05); (2) Compared with model group, for the medicine intervention group, whole blood viscosity with low shear rate, whole blood viscosity with moderate shear rate, and whole blood reduced viscosity with moderate and higher shear rate are lower than those in the control group and natural recovery group (P<0.05), respectively; The erythrocyte rigidity index and erythrocyte deformability index increase significantly (P<0.05); The thrombin time shorten could be effectively controlled in the medicine intervention group (P<0.01). The result indicates that the ASM could effectively control the blood hyperviscosity and dysfunction of blood coagulation of abnormal savda syndrome rat model.
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Received: 18 August 2011
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. Anti-cancer Effects of Uighur Medicine Abnormal Savda Munzip and Its Influence on Cell Migration[J]. , 2011, 29(11-03): 62-65. |
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. Antiproliferative Activity of Individual Herbs of Abnormal Savda Munziq on HL-60 Cells[J]. , 2009, 27(0919): 94-98. |
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2011, Vol. 29 
