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Serum Metabonomics Research on Shenxu-tanyu Syndrome Type 2 Diabetes Mellitus Based on NMR |
YOU Li1, MAMTIMIN Batur2, UPUR Halmurat2 |
1. College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830054, China;2. College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China |
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Abstract: To explore the metabolic variation and pathogenesis of type 2 diabetes mellitus of Shenxu-tanyu syndrome in Traditional Chinese Medicine (TCM) by using Nuclear Magnetic Resonance (NMR). Serum samples from 33 cases of Shenxu-tanyu syndrome type 2 diabetes mellitus patients and 50 cases of healthy people are detected and described with 1H-NMR based metabonomics, and than the data is analyzed by Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA). The results show that comparing with the healthy people, the various kinds of amino acids of Shenxu-tanyu syndrome type 2 diabetes mellitus patients are markedly lower, including isoleucine, leucine, valine, alanine, glutamate, histidine, tyrosine, phenylalanine, and 1-methylhistidine, the differences are statistically significant (P<0.05). In addition, lactate, citrate, creatine and creatinine are also markedly lower (P<0.05). However, the α-glucose and β-glucose are increased comparing with the health people (P<0.05). It is concluded that the metabolites of shenxu-tanyu syndrome type 2 diabetics are significantly different from healthy people, their tricarboxylic acid cycle and glycolysis are inhibited, protein is metabolic disorder, and branched chain amino acid is metabolic boost.
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Received: 28 December 2011
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