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| Research Progress on Inhibitors of Protein Tyrosine Phosphatase-1B |
| LIU Xia1, FENG Changgen2 |
| 1. College of Science, China Agricultural University, Beijing 100193, China;2. School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China |
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Abstract: Protein-tyrosine phosphatase-1B acts as a negative regulator of the insulin signal transduction, serving as a new therapeutic target in type 2 diabetes and obesity. Inhibitors of PTP-1B may be beneficial in the treatment of type 2 diabetes and obesity. This paper reviews recent progresses of researches on inhibitors of PTP-1B, with PTP-1B inhibitors obtained by chemical synthesis being summarized, including vanadate compounds, phosphate compounds, peptide compounds and others.
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Received: 23 February 2012
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YOU Li;MAMTIMIN Batur;UPUR Halmurat. Serum Metabonomics Research on Shenxu-tanyu Syndrome Type 2 Diabetes Mellitus Based on NMR[J]. , 2012, 30(8): 25-29. |
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MA Xinmin;LANG Jun;MA Xiaoli;LI Linlin;HAN Xue;UPUR Halmurat;TURSUN Turgun;ELI Kurban;MAMTIMIN Batur;YUNUXI Kuresi;WANG Lifeng;JIAO Yi;WANG Ye;YI Jinyang. Metabonomic Investigation on Abnormal Savda Patients with Type Two Diabetes Mellitus Using NMR Spectroscopy[J]. , 2012, 30(23): 61-66. |
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MAITISIDIKE Ayinuer;UPUR Hamulati;YU Shanjiang;ABUDULAIHAITI Wuerguli;AJI Rouzibake;YOU Lina;YANG Na;YAN Xinghai. Screening of Quantitative Diagnosis Indices of Typing Abnormal Hilit Syndrome in Uighur Medicine Using Delphi Method with 305 Cases of Type 2 Diabetes[J]. , 2012, 30(2): 39-45. |
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. Disorder of Neuro-Endocrine-Immune Network in Patients with Type-2 Diabetes Milletus and Its Clinical Significance[J]. , 2010, 28(08): 46-50. |
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. Synthesis of Coke Inhibitor Intermediate Phosphate[J]. , 2010, 28(08): 69-71. |
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2012, Vol. 30 
