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Research Progress on Inhibitors of Protein Tyrosine Phosphatase-1B |
LIU Xia1, FENG Changgen2 |
1. College of Science, China Agricultural University, Beijing 100193, China;2. School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China |
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Abstract: Protein-tyrosine phosphatase-1B acts as a negative regulator of the insulin signal transduction, serving as a new therapeutic target in type 2 diabetes and obesity. Inhibitors of PTP-1B may be beneficial in the treatment of type 2 diabetes and obesity. This paper reviews recent progresses of researches on inhibitors of PTP-1B, with PTP-1B inhibitors obtained by chemical synthesis being summarized, including vanadate compounds, phosphate compounds, peptide compounds and others.
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Received: 23 February 2012
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