Abstract:S-(+)-2,2-dimethylcyclopropane carboxamide is an important intermediate for the synthetic of medicine and pesticides, there are many synthetic methods. Up-to-date information on various synthesis methods is collected and summarized from all over the world, and the advantages and disadvantages of various synthesis methods and split methods are briefly illustrated. Based on the most recently research progresses, the asymmetric synthesis of chiral catalyst is expensive, the yield is low, optical purity and cost is hard to achieve satisfactory results. However, biocatalysis synthesis technology possesses the advantages of high selectivity, high catalytic efficiency, and without pollution. Comparing with the various synthesis methods, biological catalytic synthesis method overcomes the defects caused by the chemical synthesis process, conforms to the atom economy and sustainable development. Therefore, the method is receiving more and more attention. In the further, biocatalysis is a leading research direction.