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| Feasibility of the Magnetic Induction Hyperthermia Combined with 125I Brachytherapy |
| CAI Dongyang1, LI Li2, KONG Weicha3, ZHAO Lingyun1, TANG Jintian1 |
| 1. Key Laboratory of Particle and Radiation Imaging, Ministry of Education, Tsinghua University, Beijing 100084, China;2. Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China;3. Department of Biopharmaceuticals, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China |
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Abstract: Both alloy thermo-seed and radiation seed implanted by magnetic induction hyperthermia are at the same level with the scale. When the thermo-seed and radiation seed implant into the tumor tissue at the same time, thermal field and radiation will act together on the tumor cells, enhancing the destruction effect of tumor cell. The electromagnetic theory is applied to calculate the heat production power by thermo-seed and radiation seed in the RF magnetic field; and the thermo-seed and radiation seed are placed with different distributions into the RF magnetic field of the magnetic induction equipment in order to examine the temperature rise curve under various conditions by adjusting the magnetic field parameters. The heating effect of radiation seed in the RF magnetic field are studied in order to verify the safety of the radiation seed; with alloy thermo-seed and radiation seed are in a mixed configuration, the heating effect is studied in order to verify the effectiveness of the combined therapy. The theoretical calculations indicate that the magneto-caloric effect of radiation seed source in the RF magnetic field of magnetic induction therapy (50~500kHz) is insignificant, and the safety of hyperthermia and radiotherapy has been verified. When radiation seed mixing with thermo-seed are implanted into the agar model and the muscle tissue in vitro, the temperature in the media implanted area is far above 43℃, realizing the sensibilization that hyperthermia has on radiotherapy in the implanted-area.
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Received: 31 October 2012
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2013, Vol. 31 
