The paper studies the preparation of the fragrance microcapsule, of diameter in the range of 200-600nm and with the coefficient of dispersion less than 0.30, enjoying a long sustained-release effects, based on β-poly-malic acid (PMA) and chitosan (CS) as the wall materials. The Plackett-Burman design was adopted to select the most important nutrients and Box-Benhnken Design was used to identify the optimum concentrations of the key nutrients. The optimum conditions were determined: the chitosan concentration of 1.5g/L, the emulsification of 45min, the rotational speed of 600r/min, the reaction time of 60min, the poly (malic acid) concentration of 1.0g/L, the ratio of poly (malic acid) to chitosan of 1:2, the pH value of 6.0, the dropping speed of 7.5mL/h, and the core material amount of 1mL. In the SEM observation of the micro-spherical microcapsules, the particle size is 481.0nm, and the embedding ratio is 28.57% with a continuous long-term releasing effect.