When data are scare or monitoring is difficult in the study areas which are under the risk of contamination by reproductive health estrogens, it is necessary to evaluate the leaching migration ability of the estrogens based on their structures and activities in the environment, in order to estimate the migration ability of environmental estrogens and the groundwater contamination risk. Eighty one reproductive health estrogens were selected for the evaluation of their migration abilities in the subsurface environment based on the Groundwater Ubiquity Score method (GUS). It is shown that 69.14% of these estrogens are highly leachable, and 7.40% of them are of moderate migration ability. The GUS values of the priority toxic organic pollutants on the EPA list, i.e. estradiol, estrone, estradiol three alcohol, DDT and DDE are 3.58, 7.73, 3.19, -3.34 and -2.68, respectively; among them, estradiol three alcohol has the highest GUS value. More than twenty estrogens tested have GUS values higher than the GUS value of estradiol three alcohol. The migration abilities of these reproductive health estrogens in the subsurface environment are mainly affected by the organic carbon adsorption coefficient.