In order to guarantee the safety and mining efficiency of the high-stage second-step stopes in the high-stress situation, finite element program ANSYS is used to analyze the stability of the stopes for section-by-section excavation. And the stress and strain distribution of roof and filling body is obtained from the simulation. The result shows that the maximum tensile stress (0.21-0.39MPa), located at the roofs, is more than tensile strength (0.17MPa) of ores. The maximum pressure (0.90-2.00MPa), located at the filling body which is one meter away from the roof, approximately reach to the limitation of its pressure strength (2.00MPa). Tensile stress at roof and pressure stress of filling body with mining upwards present a declining trend. According to the hidden danger of the second-step stopes presented by numerical simulation, it is put forward to adopt medium-length hole downward sublevel drill and fill stoping with pre-protecting roof. And the combined supporting method that combines pre-stressed resin bolt, steel ban (metal net) and gunite, is used to pre-protect the roof. Support parameters are adopted based on the radius of loosening zone, which is confirmed through the numerical simulations. Effective support measures is put forward and applied to engineering tests, and then its result confirms the high safety and mining efficiency of the stope.