The adjuvant therapy of video games is developed to be a new type of treatment in recent years. Video Games and psychology principle play the important roles in the therapy, and a combination of these two methods is the key pathway in order to obtain the better effect of the adjuvant therapy. In this paper, firstly, the possible mechanism of adjuvant therapy using video games in the medical field is described. Then, the situations of virtual reality game applying in treatment of various diseases are reviewed. From the present situation, the difficulties are respectively pointed out in the views of effect, operability and position. Because of its unique interactivity and privacy advantages, the adjuvant therapy of video games is generally accepted and is regarded as a promising treatment in the medical field, however further improvement is required. To further expand the indications, professionals and systems supported in the combination of medicine and video games are the focus of further development in the future.