Bitumen contamination of Y oilfield in Iran had seriously negative effect on drilling safety and caused abandonment of several wells. In reference to aging, oxidation and solidify mechanism of heavy oil and bitumen, oxidizing material was selected optimally for bodying bitumen. The influence of testing temperature, time, and ratio of material, oxygen and drilling fluids were explored. The results showed that oxidation materials can effectively increase bitumen softening point, and bitumen was bodying under simulated formation temperature. The site test showed it is better if oxidation materials and lost circulation materials were used together. The mobility of bodying bitumen in the formation pore decreased, the sealing success rate got improved dramatically and the intrusion rate could be effectively controlled when the mud pump stopped. The difficulty of situations of complexity processing was reduced.