The medium inside the pipe, the buried way and depth, the geological and environmental conditions were always paid much attention in design codes of buried pipeline, with the influence of blast loads being ignored. Actually, more and more pipes containing combustible materials are buried under the ground, once one of them blows-up, the blast loads would certainly influence others. In this paper, dynamic response of buried pipeline under blast loads in shallow soil was stimulated by ANSYNS/LS-DYNA FEM, a 3D numerical simulation software with the basic theory and algorithm of nonlinear dynamics. The influence of amount of explosive charge and distance to explosion center to buried pipe were comparatively studied with three groups of simulation. The radial stresses of different directions were also studied to find the weakest point. The results showed amount of explosive charge and distance to explosion center both influenced the dynamic response of buried pipe. The larger the amount of charge and closer to explosion center, the bigger the stress of buried pipe suffered. Comparatively, the amount of explosive charge played a more important role. Radial stresses analyses also implied that the biggest stress presented on the farthest point right under the explosion center and the broken of buried pipe reflected to tensile stress.