In order to study the relationship between the signal transduction pathway and the disorder of the neuro-endocrine-immunity network in abnormal Savda Hilit, the blood samples of the abnormal Savda Hilit group and the non-abnormal Savda Hilit group (abnormal Kan Hilit, abnormal Belhem Hilit, abnormal Safra Hilit) were collected. After separating the white blood cell and extracting the RNA, the Affymetrix gene expression microarray technology was applied to detect the gene expression of the two groups. Then the differentially expressed genes were selected and a bioinformatic analysis was made by using the CapitalBio Molecule Annotation System (MAS) to find the genes related to the signal transduction pathway. The result of chip shows that 75 genes are up-regulated in the abnormal Savda Hilit group comparing with the non-abnormal Savda Hilit group. The bioinformatic analysis shows that 12 genes are concentrated in the signal transduction pathways of the biological process, involved in the MAPK, Toll-like receptor, the Wnt signal transduction pathway. These findings indicate that the abnormal activation of the MAPK, Toll-like receptor, the Wnt signal transduction pathway may be related to the disorder of the neuro-endocrine-immunity network in the abnormal Savda Hilit group.