The spatial and temporal variations of wind field and the atmospheric turbulence characteristics are important factors that affect the migration and dispersion of local atmospheric pollutants. Considering the complexity of meteorological and landform conditions around the inland nuclear power plant, the 3-Dimensional wind field and concentration field distribution of airborne radionuclide particle ¹³⁷Cs, aerosol ¹³¹I and conventional gas pollutant CO dispersion in the atmosphere were carried out by a 3-Dimensional CFD (computational fluid dynamics) model Fluidyn-PANACHE. This method can be used to reasonably simulate the turbulent and circumferential flow around large cooling towers in the inland nuclear power plant, compensating the shortage in subtleness of the standard Gaussian model, as well as shortage in realizing multi-wind direction simulation in the calculation by the traditional CFD model. The calculation results of annual average atmospheric dispersion factor under normal operation indicated the seasonal differences, with maximum average dispersion factor in autumn, which were consistent with those suggested by Gaussian mixture model. Consequently, it's reasonable to arrange refueling overhauling in autumn to diminish pollution. The numerical simulation results from four typical fixed wind directions were compared and they are consistent with the observed values of wind tunnel experiments, providing new references for atmospheric dispersion research and evaluation on inland nuclear power plants in China.