With exquisite biological, physical and chemical properties, cellulose nanocrystals (CNCs) have been considered as an ideal drug carrier. A novel prodrug was prepared by the covalent attachment of the tosufloxacin tosylate (TFLX) onto the surface of maleated cellulose nanocrystals (MA-CNCs) with L-leucine as a spacer. The successful coupling of MA-CNCs and TFLX was detected by fourier transformation infrared spectroscopy (FTIR). The satisfactory coverage of MA- CNCs on TFLX is shown in FE- SEM micrographs. The release behaviors of TFLX- A- MA- CNCs in simulated gastric fluid (SGF), simulated intestinal fluid (SIF) and simulated colonic fluid (SCF) were investigated. The relationship between the accumulative drug release and the fluorescence response has been evaluated. The results show that the drug was efficiently entrapped by MA-CNCs carrier and presents excellent behavior for colon specificity and may be considered as a potential material for a colon-specific drug delivery system.
TANG Lirong
,
HUANG Biao
,
LI Tao
,
LU Qilin
,
CHEN Xuerong
. Functionalized Cellulose Nanocrystals as a Carrier for Colon-targeted Drug Delivery System[J]. Science & Technology Review, 2014
, 32(4-5)
: 22
-28
.
DOI: 10.3981/j.issn.1000-7857.2014.h1.002
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