Spescial Issues

Research Progress in the Treatment of Melanoma

  • GUO Jun
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  • Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education; Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Beijing Institute for Cancer Research, Beijing 100142, China

Received date: 2014-08-12

  Revised date: 2014-08-15

  Online published: 2014-09-26

Abstract

Melanoma is an aggressive malignant tumor with poor prognosis by traditional therapies. Since 2011, the tyrosine kinase inhibitor drugs such as BRAF inhibitors (Vemurafenib, Dabrafenib) and MEK inhibitor (Trametinib) have brought a hope. Whereas new immunological therapy drugs, including anti-CTLA-4 antibody (Ipilimumab) and anti-PD-1/PD-L1 antibody, have brought a brain storm to the melanoma therapy. The modes of treatment of melanoma are gradually getting rid of the traditional treatment strategy and entering a new historical stage. In the foreseeable future, the research of some new targets, various small molecular targeted drugs, immune targeting therapy of drugs, as well as combination of small molecule targeted drugs and immune targeting drugs will be the mainstream treatment of melanoma. A new era of melanoma therapy is coming. This paper briefly summarizes the advances of molecule-targeted chemotherapy, immunological therapy and chemotherapy.

Cite this article

GUO Jun . Research Progress in the Treatment of Melanoma[J]. Science & Technology Review, 2014 , 32(26) : 15 -21 . DOI: 10.3981/j.issn.1000-7857.2014.26.001

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