Science & Technology Review >

2014 , Vol. 32 >Issue 30: 19 - 24

DOI: https://doi.org/10.3981/j.issn.1000-7857.2014.30.002

Recent Advances in Noninvasive Ultrasound Monitoring of Thermal Therapy for Tumors

  • ZHOU Zhuhuang ,
  • WU Weiwei ,
  • WU Shuicai ,
  • YANG Chunlan ,
  • LIN ChungChih ,
  • TSUI PoHsiang
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  • 1. College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China;
    2. College of Electronic Information and Control Engineering, Beijing University of Technology, Beijing 100124, China;
    3. Department of Computer Science and Information Engineering, Chang Gung University, Taiwan 333, China;
    4. Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taiwan 333, China

Received date: 2014-08-13

  Revised date: 2014-08-15

  Online published: 2014-11-14

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Abstract

Thermal therapy is a technique to kill tumor cells with heat and has become an important means for tumor treatment. It can be divided into conventional hyperthermia (41-45℃) and thermal ablation (>60℃). For thermal therapy, noninvasive monitoring of tissue temperature distribution and thermal lesion (coagulation zone) formation in the treatment area is the key to guaranteeing treatment safety and efficacy. In this review, recent advances in noninvasive ultrasound-based temperature estimation and thermal lesion detection techniques are presented. Noninvasive ultrasound temperature estimation is based on temperature dependence of such parameters as speed of sound and thermal expansion, ultrasound attenuation coefficient, backscattered energy, and B-mode ultrasound image texture feature. Noninvasive ultrasonic thermal lesion detection is based on ultrasound tissue characterization techniques. These techniques include the Nakagami statistical model, ultrasound attenuation, integrated backscatter, ultrasound elasticity imaging, mean scatterer spacing, and low-frequency acoustic emission. Future developments of noninvasive ultrasound monitoring techniques for thermal therapy are discussed. Future work may include the study of monitoring precision validation, adaptive parameter adjustment for tissue interindividual difference, reducing tissue movement interference, multi-dimensional and multi-parameter monitoring, realtime computing, and the establishment of the thermal therapy experimental data center.

Key words： tumor; thermal therapy; ultrasound; noninvasive monitoring

Cite this article

ZHOU Zhuhuang , WU Weiwei , WU Shuicai , YANG Chunlan , LIN ChungChih , TSUI PoHsiang . Recent Advances in Noninvasive Ultrasound Monitoring of Thermal Therapy for Tumors[J]. Science & Technology Review, 2014 , 32(30) : 19 -24 . DOI: 10.3981/j.issn.1000-7857.2014.30.002

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