This paper investigates the relationship between the polymorphisms of ACE gene and the breast cancer with abnormal Hilit in Chinese Han population in Xinjiang. The breast caner patients are divided into four groups according to body fluids based on the Uighur medicine theory, the polymerase chain reaction technique is employed to detect the genotype and the allele frequencies of the I/D polymorphism in the ACE gene in 124 breast cancer patients with abnormal Hilit and 72 normal control subjects in the Han population in Xinjiang. It is shown that the frequency of the I allele and the II genotype is significantly higher in the breast caner patients with abnormal balgham Hilit than in the control (P=0.004; P=0.018); the frequency of the I allele is significantly higher in the breast caner patients with abnormal balgham Hilit than in the breast caner patients with abnormal black Savda (P=0.012). It is concluded that the I allele and the II genotype in ACE gene may increase the risk of breast cancer with Uighur medicine abnormal balgham Hilit.
PENG Xiaomei, UPUR Halmurat, SONG Manshu, MUTALLIP Dilnur, MAMATYUSUPU Dolikun
. Polymorphism and Susceptibility of Angiotensin Converting Enzyme (ACE) Gene to Breast Cancer with Abnormal Hilit[J]. Science & Technology Review, 2014
, 32(36)
: 65
-68
.
DOI: 10.3981/j.issn.1000-7857.2014.36.010
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