This paper compares differences in depression and quality of life between abnormal savda and non-abnormal savda type HIV/AIDS patients to investigate the influence of abnormal savda on depression and health-related quality of life of HIV/AIDS patients. According to abnormal body fluid classification criteria in traditional Uyghur medicine, 307 HIV/AIDS patients were differentiated, and their depression status and quality of life were assessed using HAMD and MOS- HIV scales. Syndrome differentiation results revealed that abnormal savda type patients accounted for 61.6%, while non- abnormal savda type patients (abnormal khan, sapara and belhem syndrome types) accounted for 38.4%. The proportion of patients with depression in total number of abnormal savda type HIV/AIDS patients was greater than that in non-abnormal savda patients (P<0.05). The average scores of mental health from MOS-HIV quality of life scale were lower in abnormal savda patients than that in non-abnormal savda patients (P< 0.05); however, the difference in average scores of physical health was not statistically significant (P>0.05). The average scores of physical function, cognitive function and role transition in abnormal savda patients were higher than that in non-abnormal savda syndrome patients (P<0.05), but the average scores of four subscales including social function, mental health, fatigue/energy, and health pressure were lower (P<0.05). The main syndrome type in HIV/AIDS patients was abnormal savda syndrome. Compared to nonabnormal savda syndrome patients, depression was more common in abnormal savda syndrome type patients, and has quite severe effects on quality of life, which should be noticed and intervened with traditional Uyghur medication to improve patient's healthrelated quality of life.
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