Reviews

Research advances in the mechanism of histone methylation recognition by reader modules

  • ZHAO Shuai ,
  • SU Xiaonan ,
  • LI Yuanyuan ,
  • LI Haitao
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  • Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China

Received date: 2014-11-21

  Revised date: 2015-01-08

  Online published: 2015-05-05

Abstract

As a major mechanism for the epigenetic regulation, the histone methylation has a crucial impact on the decoding of the genetic information. The histone methylation can be recognized by a class of so-called "reader" modules to mediate the downstream functional outcomes. In this paper, we review the structural aspects of the reported histone methylation readers (e.g. "royal family" members, PHD finger, BAH), and illustrate the molecular basis underlying the site- and state- specific readouts of the histone methylation. This review also covers the concepts of the combinatorial readout and the modification crosstalk in the epigenetic regulation.

Cite this article

ZHAO Shuai , SU Xiaonan , LI Yuanyuan , LI Haitao . Research advances in the mechanism of histone methylation recognition by reader modules[J]. Science & Technology Review, 2015 , 33(8) : 94 -100 . DOI: 10.3981/j.issn.1000-7857.2015.08.016

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