The present study investigated the anti-fatigue effects of Panax ginseng oligopeptide of Jilin. 336 male ICR mice of SPF were randomized divided into 7 groups: control group, whey protein group, and other five groups of panax ginseng oligopeptide of Jilin at doses of 0.125, 0.250, 0.500, 1.000, 2.000 g/kg, respectively. After being fed for 30 days, the loading swimming time was determined by swimming experiment. The content of blood urea nitrogen and the activity of lactic dehydrogenase were measured by an automatic biochemical analyzer. The level of blood lacticacid in mouce was detected by ultraviolet spectrophotometer, and the liver glycogen of mouce was measured according to the kit. There were no significant differences between the control group and whey protein group in terms of the above indicators. Compared with the whey protein group, Panax ginseng oligopeptide of Jilin could significantly increase the burden swimming time, decrease the content of blood urea nitrogen and lactic acid, improve the activity of lactic dehydrogenase and increase the content of liver glycogen in mouce. Thus, it is concluded that panax ginseng oligopeptide of Jilin has excellent anti-fatigue effects in mouce.
BAO Lei
,
WANG Junbo
,
CAI Xiaxia
,
ZHANG Yuan
,
SUN Bin
,
ZHANG Zhaofeng
,
LI Yong
. Anti-fatigue effects of Panax ginseng oligopeptide of Jilin Province[J]. Science & Technology Review, 2015
, 33(13)
: 56
-60
.
DOI: 10.3981/j.issn.1000-7857.2015.13.009
[1] 中国行业研究网. 2012 年卫生部批准人参为新资源食品[EB/OL]. 2012-09-04. http://www.chinairn.com/news/20120905/636059.html. ChinaIRN. Ministry of Health approved a new resource food ginseng in 2012[EB/OL]. 2012- 09- 04. http://www.chinairn.com/news/20120905/ 636059.html.
[2] 王筠默. 人参药理研究的进展[J]. 人参研究, 2001, 13(3): 2-7. Wang Junmo. Ginseng pharmacological research progress[J]. Ginseng Research, 2001, 13(3): 2-7.
[3] KangSY,Schini-KerthVB,KimND.Ginsenosidesofthe protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta[J]. Life Sciences, 1995, 56(19): 1577-1586.
[4] 张晓芬, 任伯成, 张青森. 人参抗运动疲劳作用的实验研究[J]. 中医药 学报, 1995, 6(6): 29. Zhang Xiaofen, Ren Bocheng, Zhang Qingsen. Experimental study of anti- fatigue effects of ginseng[J]. Acta Chinese Medicine and Pharmacology, 1995, 6(6): 29.
[5] Ando T, Muraoka T, Yamasaki N, et al. Preparation of anti-lipolytic substance from Panax ginseng[J]. Planta Medica, 1980, 38(1): 18-23.
[6] 王本样, 杨明, 金玉莲, 等. 人参多肽降血糖机制的研究[J]. 药学学 报, 1990, 25(6): 401-405. Wang Benyang, Yang Ming, Jin Yulian, et al. Studies on the mechanism of ginseng polypeptide induced hypoglycemia[J]. Acta Pharmaceutica Sinica, 1990, 25(6): 401-405.
[7] 张今, 杜文媛, 张红缨, 等. 胰岛素样人参肽的氨基酸序列测定[J]. 吉 林大学自然科学学报, 1988, 4: 75-78. Zhang Jin, Du Wenyuan, Zhang Hongying, et al. Analysis on the amino acid sequence of insulin- like ginseng peptide[J]. Journal of Jilin University, 1988, 4: 75-78.
[8] 刘雪梅, 陈文学, 杨铭, 等. 人参糖肽结合耐力运动对糖尿病大鼠降 血糖作用及其机制研究[J]. 中国体育科技, 2014, 50(6): 134-140. Liu Xuemei, Chen Wenxue, Yang Ming, et al. Studies on hypoglycemic effect and mechanism of the ginseng glycopeptide combined endurance exercise on diabetic rats[J]. China Sport Science and Technology, 2014, 50(6): 134-140.
[9] 李勇. 肽临床营养学[M]. 北京: 北京大学医学出版社, 2012: 1-3. Li Yong. Peptide clinical nutrition[M]. Beijing: Peking University Medical Press, 2012: 1-3.
[10] 卫生部卫生监督司. 保健食品的功能学评价程序和检验方法[M]. 北 京: 人民卫生出版社, 2003. Health Supervision Department of the Ministry of Health. The functional evaluation procedure and the test method of health food[M]. Beijing: People's Medical Publishing House, 2003.
[11] 鲍蕾蕾, 陈海飞, 卞俊, 等. 复方灵芝孢子精油软胶囊抗疲劳耐缺氧 能力研究[J]. 中国实验方剂学杂志, 2014, 20(14): 130-132. Bao Leilei, Chen Haifei, Bian Jun, et al. Effect of compound ganoderma lucidum spore oil soft capsule on antifatigue property and oxygen deficit- tolerance in mice[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2014, 20(14): 130-132.
[12] 刘迪, 尚华, 宋晓宇. 杜仲叶树脂分离纯化产物的抗疲劳功效[J]. 食 品科学, 2013, 34(5): 251-254. Liu Di, Shang Hua, Song Xiaoyu. Antifatigue effect of extract from eucommia ulmoides leaves purified by resin[J]. Food Science, 2013, 34 (5): 251-254.
[13] 蒲玲玲, 郭长江. 乳清蛋白的组成及其主要保健功能[J]. 中国食物与 营养, 2011, 17(6): 68-70. Pu Lingling, Guo Changjiang. Composition and major health functions of whey protein[J]. Food and Nutrition in China, 2011, 17(6): 68-70.
[14] 伏育平. 运动性中枢疲劳的生理学研究进展[J]. 南京体育学院学报: 自然科学版, 2004, 3(2): 30-33. Fu Yuping. Research progress of central neural system fatigue in physiology[J]. Journal of Nanjing Institute of Physical Education: Natural Science, 2004, 3(2): 30-33.
[15] 李清宇, 杨颖, 贾琳斐, 等. 板栗多糖的分离纯化、结构分析及抗疲 劳作用的研究[J]. 食品与生物技术学报, 2013, 32(7): 767-772. Li Qingyu, Yang Ying, Jia Linfei, et al. Purification, structural analysis and antifatigue assay of polysaccharide from castanea mollissima blume[J]. Journal of Food Science and Biotechnology, 2013, 32(7): 767-772.
[16] 孙晓波, 魏菲. 人参对老化机体某些生理生化指标的影响[J]. 老年学 杂志, 1989, 9(1): 59-61. Sun Xiaobo, Wei Fei. The effects of ginseng on some physiological and biochemical indexes in aging body[J]. Chinese Journal of Gerontology, 1989, 9(1): 59-61.
[17] 刘杰, 杜学海, 傅芳婷, 等. 人参皂甙清除反应性氧代谢产物预防大 鼠膜性肾病[J]. 肾脏病与透析肾移植杂志, 1995, 4(1): 29-31. Liu Jie, Du Xuehai, Fu Fangting, et al. Ginseng saponins remove the reactive oxygen metabolites to prevent membranous nephropathy in rats[J]. Chinese Journal of Nephrology Dialysis & Transplantation, 1995, 4(1): 29-31.
