A review on regulation of Rev-erbs in energy homeostasis and research prospect in sports science

  • SHEN Youqing ,
  • HUANG Guoyuan
  • 1. Department of Physical Education, Hubei University of Education, Wuhan 430205, China;
    2. Department of Sport Science, University of Southern Indiana, Evansville 47712, USA

Received date: 2015-11-30

  Revised date: 2016-10-18

  Online published: 2017-02-07


Nuclear receptor Rev-erbs have mainly two subtypes, Rev-erbα and Rev-erbβ, which are widely expressed but mainly prevalent in tissues and organs of mammalians that have predominantly metabolic functions. The expression level of Rev-erbs can be influenced by various factors such as high calorie diet, medicine, and exercise intervention. Rev-erbs are essential to regulate glucose and lipid metabolism, insulin secretion, and blood glucose homeostasis, and are the therapeutic target of chronic diseases such as obesity and diabetes. Rev-erbs may maintain energy homeostasis through related signaling pathway of glucose and lipid metabolism. Recent researches indicate that exercise regiments stimulate Rev-erbs expressions in liver and skeletal muscle and maintain lipid homeostasis, which would be the core mechanism of exercise intervention to chronic diseases. This review analyzes the bioactivity and the mechanism of Rev-erbs, and proposes future studies on Rev-erbs in the sphere of sports science.

Cite this article

SHEN Youqing , HUANG Guoyuan . A review on regulation of Rev-erbs in energy homeostasis and research prospect in sports science[J]. Science & Technology Review, 2016 , 34(24) : 56 -61 . DOI: 10.3981/j.issn.1000-7857.2016.24.007


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