The investigation of bio-organic chemistry focuses on elucidation of the mechanisms involved in complex biological systems, as well as the design and optimization of efficient biomacromolecule-based catalysts for organic synthesis. In this paper, we select several representative papers published on Science, Nature, PNAS, Nature Chemistry, etc. to summarize the most important progress in this research field.
ZHENG Qingfei
,
WANG Shoufeng
. When organic chemistry meets biological science: Recent advances in bio-organic chemistry in 2016[J]. Science & Technology Review, 2017
, 35(1)
: 21
-29
.
DOI: 10.3981/j.issn.1000-7857.2017.01.003
[1] Wright T H, Bower B J, Chalker J M, et al. Posttranslational mutagenesis:A chemical strategy for exploring protein side-chain diversity[J]. Science, 2016, 354(6312):597-608.
[2] Adams S R, Mackey M R, Ramachandra R, et al. Multicolor electron microscopy for simultaneous visualization of multiple molecular species[J]. Cell Chemical Biology, 2016, 23(11):1417-1427.
[3] Tan D, Li Q, Zhang M J, et al. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states[J]. eLife, 2016, 5:e12509.
[4] Zheng Q, Wang S, Duan P, et al. An α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization[J]. Proceedings of the National Academy of Sciences, 2016, 113(50):14318-14323.
[5] Key H M, Dydio P, Clark D S, et al. Abiological catalysis by artificial haem proteins containing noble metals in place of iron[J]. Nature, 2016, 534(7608):534-537.
[6] Dydio P, Key H M, Nazarenko A, et al. An artificial metalloenzyme with the kinetics of native enzymes[J]. Science, 2016, 354(6308):102-106.
[7] Kan S B J, Lewis R D, Chen K, et al. Directed evolution of cytochrome C for carbon-silicon bond formation:Bringing silicon to life[J]. Science, 2016, 354(6315):1048-1051.
[8] Wang Z, Xu W, Liu L, et al. A synthetic molecular system capable of mirror-image genetic replication and transcription[J]. Nature Chemistry, 2016(8):698-704.
[9] Sakimoto K K, Wong A B, Yang P. Self-photosensitization of nonphotosynthetic bacteria for solar-to-chemical production[J]. Science, 2016, 351(6268):74-77.
[10] Schwander T, von Borzyskowski L S, Burgener S, et al. A synthetic pathway for the fixation of carbon dioxide in vitro[J]. Science, 2016, 354(6314):900-904.
[11] Zheng Q, Guo Y, Yang L, et al. Enzyme-dependent[4+2] cycloaddition depends on lid-like interaction of the N-terminal sequence with the catalytic core in PyrI4[J]. Cell Chemical Biology, 2016, 23(3):352-360.
