The glioma is the most common and lethal malignant tumor in the central nervous system. The malignant progression and the poor prognosis could be traced to its polyclonal origin, the heterogeneity and the chemo-/radio-therapy resistance. The classical pathology is based on the morphology criteria, which could not reflect the genetic alterations and has a limited prognostic implication. It is an urgently task to construct the histology and the molecular biomarker based the detection system. With the development of the high-throughput and biological technique, great progresses have been made in the identification of the multi-omics-based classification and the detection of the biomarker, to provide a basis for the regulatory network exploration, the target discovering, the drug selection and the clinical application.
LIU Yuqing
,
LIU Xing
,
JIANG Tao
. Advances of molecular classification and pathology in glioma diagnosis and treatment[J]. Science & Technology Review, 2017
, 35(4)
: 64
-67
.
DOI: 10.3981/j.issn.1000-7857.2017.04.011
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