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Cryo-clectron microscopy:Commentary on the 2017 Nobel Prize in Chemistry

  • WANG Hongwei
  • School of Life Sciences Tsinghua University;Beijing Advanced Innovation Center for Structural Biology, Beijing 100084, China

Received date: 2017-11-15

  Revised date: 2017-11-23

  Online published: 2017-12-16


The 2017 Nobel Prize for Chemistry was awarded to three scientists (Jacques Dubochet, Joachim Frank and Richard Henderson) for developing cryo-electron microscopy for high-resolution structure determination of biomolecules in solutions. This commentary describes the development of cryo-electron microscopy, three-dimensional reconstruction of macromolecules, major technology breakthroughs leading to the recent uprising of cryo-electron microscopy, and the future perspective of the field.

Cite this article

WANG Hongwei . Cryo-clectron microscopy:Commentary on the 2017 Nobel Prize in Chemistry[J]. Science & Technology Review, 2017 , 35(23) : 16 -21 . DOI: 10.3981/j.issn.1000-7857.2017.23.002


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