The title compound spiro[indoline-3,3'-pyrrolizin]-2-one C27H24ClN3O2 is synthesized by the one-pot multicomponent reaction of chalcone, 5-methylisatin and proline in trace amounts of methanol under stirring at 60℃. Its structure is determined by single crystal X-ray diffraction. The crystal is monoclinic, space group P2(1)/c, with Mr=504.01, a=0.84907(6) nm, b=1.07072(9) nm, c=2.9121(4) nm, V=2.6415 (5) nm3, Z=4, Dc=1.267 mg/m3, μ=0.180 mm-1, and F(000)=1064. The structure is solved by direct methods and refined by full-matrix least squares method to the final R=0.0657 and ωR=0.1376. X-ray analysis reveals that the newly formed ring of tetrahydropyrrole in the crystal structure is of envelope conformation.
XU Linlin
,
ZHU Xiaotong
,
ZHANG Jinpeng
. Construction and characterization of spiro[indoline-3,3'-pyrrolizin]-2-one skeleton[J]. Science & Technology Review, 2017
, 35(23)
: 58
-61
.
DOI: 10.3981/j.issn.1000-7857.2017.23.009
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