Immune checkpoint blockade and other cancer immunotherapies have achieved great success in clinic but problems such as low response rate still remain. Cholesterol is a key component of cell membrane, whose cellular metabolism can influence the plasma membrane environment and effector function of T cells. We have found that the anti-tumor immune response of CD8+ T cells can be potentiated by modulating cellular cholesterol metabolism. Inhibiting the activity of ACAT1, a key cholesterol esterification enzyme, can upregulate the cholesterol level on CD8+ T cell plasma membrane, and significantly enhance the anti-tumor effector function. This finding provides a new method for cancer immunotherapy.
BAI Yibing
,
XU Chenqi
. A new cancer immunotherapy based on cholesterol metabolism modulation[J]. Science & Technology Review, 2018
, 36(7)
: 33
-36
.
DOI: 10.3981/j.issn.1000-7857.2018.07.005
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