Think Tank

New ideas to prevent and control infectious diseases via exploring symbiotic characteristics between human and microorganism

  • ZHANG Chenggang
Expand
  • School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China

Received date: 2019-03-15

  Revised date: 2019-10-06

  Online published: 2020-08-14

Abstract

In recent years there have been a large number of troubles caused by infectious diseases and biological safety incidents, such as the SARS in 2003 and the MERS event. In addition the rapid development of synthetic biology technology in artificial life has probably accelerated the threat of infectious diseases. The situation of biological safety is becoming more serious and looking for effective control and prevention. In this article, taking the scientific and technological progress in recent years and the related works in our laboratory in gut flora and chronic disease control and prevention we propose some new ideas of prevention and control of infectious diseases by exploring symbiotic characteristics between human and microorganism. It may be an alternative choice for us to understand that the microorganisms should also have reasonable rights to live in the environment. The reasonable relationship between human beings and symbiotic microorganism should be a win-win mode through protecting and optimizing the symbiotic microorganism system to improve human immunity. Therefore, it is important to provide new ideas for prevention and control of infectious diseases and biological safety by living with microorganisms in peace.

Cite this article

ZHANG Chenggang . New ideas to prevent and control infectious diseases via exploring symbiotic characteristics between human and microorganism[J]. Science & Technology Review, 2020 , 38(15) : 59 -66 . DOI: 10.3981/j.issn.1000-7857.2020.15.007

References

[1] 徐光宪. 21世纪是信息科学、合成化学和生命科学共同繁荣的世纪[J]. 化学通报, 2003, 66(1):3-11.
[2] 21世纪的生命科学:邹承鲁教授访谈录[J]. 生物化学与生物物理进展, 2000, 27(1):3-5.
[3] Hu B, Ge X, Wang L F, et al. Bat origin of human coronaviruses[J]. Virology Journal, 2015, 12(1):1-10.
[4] Gire S K, Goba A, Andersen K G, et al. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak[J]. Science, 2014, 345(6202):1369-1372.
[5] Su S, Wong G, Liu Y, et al. MERS in South Korea and China:a potential outbreak threat?[J]. Lancet, 2015, 385(9985):2349-2350.
[6] Liu Y, Liu J, Du S, et al. Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes[J]. Nature, 2017, 545(7655):482-486.
[7] Gibson D G, Benders G A, Andrews-Pfannkoch C, et al. Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome[J]. Science, 2008, 319(5867):1215-1220.
[8] 李鹏媛, 原丽红, 陆家海. 应对新发传染病, One Health策略势在必行[J].传染病信息, 2018, 31(1):11-14, 54.
[9] 张成岗. 当前慢病防控困境迫切呼唤新医学和菌心说[J]. 科技导报, 2015, 33(22):106-111.
[10] 张成岗, 巩文静. 基于饥饿源于菌群的新发现将引发慢病防控突破性进展[J]. 科技导报, 2017, 35(21):43-48.
[11] 孟昭鹏. 十大常见传染病[J]. 传染病信息, 1996(4):147-147.
[12] 陈章良.《科技导报》 热烈庆祝屠呦呦先生获得诺贝尔奖[J]. 科技导报, 2015, 33(20):2.
[13] 秦恩强. 埃博拉病毒病的研究进展[J]. 中华现代护理杂志, 2014, 20(35):4409-4410.
[14] 张泽, 胡嘉华, 陈佳琳, 等. AME诺贝尔故事06|病原细菌学奠基人科赫[J]. 临床与病理杂志, 2015, 35(8):1478-1480.
[15] 理查德·道金斯, 卢允中. 自私的基因[M]. 北京:中信出版社, 2012.
[16] 巩文静, 黄清健, 高大文, 等. 柔性辟谷技术在青年人群体重控制中的应用[J]. 军事医学, 2016, 40(8):651-656.
[17] 任青河, 黄江南, 黄荣杰, 等. 柔性辟谷技术改善高血压的初步研究[J]. 中国食物与营养, 2017, 23(8):70-75.
[18] 张成岗, 巩文静. 柔性辟谷:一种可改善肥胖及相关慢性病的新技术[J]. 中国民康医学, 2018, 30(6):100-102.
[19] 张成岗. 新医学·菌心说·云医院[M]. 北京:中医古籍出版社, 2016.
[20] Ren Q H, Gong W J, Huang R J, et al. The flexible fasting technology can improve hypertension:A pilot study in self-controlled designs[J]. Trends in Medicine, 2019, 19(5):1-8.
[21] Gong W, Sun C, Teng S, et al. Evaluation of a novel fasting approach using plant polysaccharides per meal in human symbionts[J]. Integrative Clinical Medicine, 2018, 2(2):1-12.
[22] Xu J, Gordon J I. Honor thy symbionts[J]. PNAS, 2003, 100(18):10452-10459.
[23] Zhang C. The gut flora-centric theory based on the new medical hypothesis of "hunger sensation comes from gut flora":A new model for understanding the etiology of chronic diseases in human beings[J]. Austin Internal Medicine, 2018, 3(3):1030-1036.
[24] Zhang C G, Gong W J, Li Z H, et al. A biological hypothesis:Is it possible that human symbiotic microbiota coding hunger genes for human beings[J]. Journal of Advances in Health, 2019, 1(2):145-148.
[25] Zhang C G, Gong W J, Li Z H, et al. Research progress of gut flora in improving human wellness[J]. Food Science and Human Wellness, 2019, 8(2):102-105.
[26] Sender R, Fuchs S, Milo R. Are we really vastly outnumbered? revisiting the ratio of bacterial to host cells in humans[J]. Cell, 2016, 164(3):337-340.
[27] Shukla S K, Cook D, Meyer J, et al. Changes in gut and plasma microbiome following exercise challenge in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)[J]. PLoS One, 2015, 10(12):e0145453.
[28] Yamamura T, Ono H, Sato W. Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)[J]. Brain Nerve, 2018, 70(1):35-40.
[29] Mao K, Baptista A P, Tamoutounour S, et al. Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism[J]. Nature, 2018, 554(7691):255-259.
[30] 李军梅, 刘刚, 邓永红. 吸入抗生素治疗肺部感染的研究进展[J]. 重庆医学, 2008, 37(4):432-434.
[31] 王英杰. 肝衰竭并发细菌感染与抗生素治疗[J]. 实用肝脏病杂志, 2014, 17(2):117-120.
[32] 张思敏, 徐俊, 李俊华. 乌司他丁增强抗生素治疗儿童细菌致脓毒血症疗效的机制研究[J]. 中国生化药物杂志, 2014, 34(2):135-137.
[33] 马丁·布莱泽, 傅贺, 严青. 消失的微生物:滥用抗生素引发的健康危机[M]. 长沙:湖南科学技术出版社, 2016.
[34] 李华凤. 从《物种起源》 到《人类的由来》[D]. 沈阳:沈阳工业大学, 2011.
[35] 达尔文, 叶笃庄, 杨习之. 人类的由来及性选择[M]. 北京:北京大学出版社, 2009.
[36] 吴晓阳. 基于16S rDNA的豺、狼、家犬肠道微生态研究[D]. 曲阜:曲阜师范大学, 2016.
[37] 罗永久, 钟志军, 彭广能, 等. 不同食性动物肠道菌群的ERIC-PCR指纹图谱分析[J]. 中国兽医学报, 2014, 34(11):1764-1769.
[38] 赵晗旭. 不同野生动物肠道微生物多样性分析及功能初步研究[D]. 长春:吉林农业大学, 2015.
[39] 张小杰, 曾俊棋, 王丽娟, 等. 高通量16S测序法比较不同食性猪肠道细菌结构差异[C]//浙江省动物学会第十二届会员代表大会暨学术讨论会论文摘要集. 杭州:浙江省动物学会, 2013:1.
[40] 张成岗, 巩文静, 李志慧, 等. 菌心进化论:一种对于动物进化的新理解[J]. 生物信息学, 2018, 16(4):203-213.
[41] de la Fuente-Nunez C, Meneguetti BT, Franco OL, et al. Neuromicrobiology:How microbes influence the brain[J]. ACS Chemical Neuroscience, 2018, 9(2):141-150.
Outlines

/