[1] Whiteford H A, Ferrari A J, Degenhardt L, et al. The global burden of mental, neurological and substance use disorders:An analysis from the global burden of disease study 2010[J]. PloS One, 2015, 10(2):e0116820.
[2] Tang S W, Helmeste D M, Leonard B E. Neurodegeneration, neuroregeneration, and neuroprotection in psychiatric disorders[J]. Mod Trends Pharmacopsychiatry, 2017, 31:107-123.
[3] Seo D Y, Lee S R, Heo J W, et al. Ursolic acid in health and disease[J]. Korean Journal of Physiology and Pharmacology, 2018, 22(3):235-248.
[4] Shi Y J, Chen X P, Li Y C, et al. Ursolic acid:Is a better hope against liver injury caused by diabetes mellitus[J]. Latin American Journal of Pharmacy, 2017, 36:723-729.
[5] James S L, Theadom A, Ellenbogen R G, et al. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016:A systematic analysis for the global burden of disease study 2016[J]. The Lancet Neurology, 2019, 18(1):56-87.
[6] Ding H, Wang H, Zhu L, et al. Ursolic acid ameliorates early brain injury after experimental traumatic brain injury in mice by activating the Nrf2 pathway[J]. Neurochemical Research, 2017, 42(2):337-346.
[7] Boldrini M, Fulmore C A, Tartt A N, et al. Human hippocampal neurogenesis persists throughout aging[J]. Cell Stem Cell, 2018, 22(4):589-599.
[8] Spalding K, Bergmann O, Alkass K, et al. Dynamics of hippocampal neurogenesis in adult humans[J]. Cell, 2013, 153(6):1219-1227.
[9] Solomon H. Molecular pharmacology of rosmarinic and salvianolic acids:Potential seeds for alzheimer's and vascular dementia drugs[J]. International Journal of Molecular Sciences, 2018, 19(2):458-482.
[10] Sahu S, Li R, Kadeyala P K, et al. The human natural killer-1(HNK-1) glycan mimetic ursolic acid promotes functional recovery after spinal cord injury in mouse[J]. The Journal of Nutritional Biochemistry, 2018, 55:219-228.
[11] 陈鹏, 丁志杰. 熊果酸对大鼠局灶性脑缺血再灌注损伤的保护作用[J]. 中国实验方剂学杂志, 2015, 21(12):129-133.
[12] Li L, Zhang X, Cui L, et al. Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice[J]. Brain Research, 2013, 1497:32-39.
[13] 李俐涛. 熊果酸对局灶性脑缺血再灌注损伤小鼠的脑保护作用及其信号转导机制研究[D]. 石家庄:河北医科大学, 2011.
[14] 李利涛, 张祥建, 崔丽丽, 等. 熊果酸在缺血性脑血管病中发挥神经保护作用的机制:激活Nrf2信号通路[C]//中华医学会第十七次全国神经病学学术会议论文汇编(下). 厦门:中华医学会, 2014:115.
[15] Fan F, Yang J, Xu Y, et al. MiR-539 targets MMP-9 to regulate the permeability of blood-brain barrier in ischemia/reperfusion injury of brain[J]. Neurochem Res, 2018, 43(12):2260-2267.
[16] Wang Y, He Z, Deng S. Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury[J]. Drug Design, Development and Therapy, 2016, 10:1663-1674.
[17] Wang L, Lei L, Deng S, et al. Ursolic acid ameliorates inflammation in cerebral ischemia and reperfusion injury possibly via high mobility group box 1/toll-like receptor 4/NFκB pathway[J]. Frontiers in Neurology, 2018, 9(253):1-12.
[18] Zhang T, Su J, Guo B, et al. Ursolic acid alleviates early brain injury after experimental subarachnoid hemorrhage by suppressing TLR4-mediated inflammatory pathway[J]. International Immunopharmacology, 2014, 23(2):585-591.
[19] Zhang T, Su J, Wang K, et al. Ursolic acid reduces oxidative stress to alleviate early brain injury following experimental subarachnoid hemorrhage[J]. Neuroscience Letters, 2014, 579:12-17.
[20] 张婷婷, 梁国标, 苏静缘, 等. 熊果酸对大鼠蛛网膜下腔出血早期脑损伤和基质金属蛋白酶-9的影响[J]. 中国现代应用药学, 2015, 32(8):911-914.
[21] Takahashi R H, Nagao T, Gouras G K. Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease[J]. Pathology International, 2017, 67(4):185-193.
[22] Liang W, Zhao X, Feng J, et al. Ursolic acid attenuates beta-amyloid-induced memory impairment in mice[J]. Arquivos de Neuro-psiquiatria, 2016, 74(6):482-488.
[23] Yoon J, Youn K, Ho C, et al. p-Coumaric acid and ursolic acid from corni fructus attenuated β amyloid(25-35)-induced toxicity through regulation of the NF-κB signaling pathway in PC12 cells[J]. Journal of Agricultural and Food Chemistry, 2014, 62:4911-4916.
[24] Hong S Y, Jeong W S, Jun M. Protective effects of the key compounds isolated from corni fructus against β-amyloid-induced neurotoxicity in PC12 Cells[J]. Molecules, 2012, 17(9):10831-10845.
[25] Stewart C R, Stuart L M, Wilkinson K, et al. CD36 ligands promote sterile inflammation through assembly of a toll-like receptor 4 and 6 heterodimer[J]. Nature Immunology, 2010, 11(2):155-161.
[26] Wilkinson K, Boyd J D, Glicksman M, et al. A high content drug screen identifies ursolic acid as an inhibitor of amyloid protein interactions with its receptor CD36[J]. Journal of Biological Chemistry, 2011, 286(40):34914-34922.
[27] Ferreira-Vieira T H, Guimaraes I M, Silva F R, et al. Alzheimer's disease:Targeting the cholinergic system[J]. Current Neuropharmacology, 2016, 14(1):101-115.
[28] Hitzeman N. Cholinesterase inhibitors for Alzheimer's disease[J]. American Family Physician, 2006, 74(5):747-749.
[29] Bahadori M B, Dinparast L, Valizadeh H, et al. Bioactive constituents from roots of Salvia syriaca L:Acetylcholinesterase inhibitory activity and molecular docking studies[J]. South African Journal of Botany, 2016, 106:1-4.
[30] Qian W, Hui Z, Ming L, et al. P38 MAPK signaling pathway regulates nuclear factor-κB and inducible nitric oxide synthase expressions in the substantia nigra in a mouse model of Parkinson's disease[J]. Journal of Southern Medical University, 2014, 34(8):1176-1180.
[31] Mortiboys H, Thomas K J, Koopman W J H, et al. Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts[J]. Annals of Neurology, 2008, 64(5):555-565.
[32] Rai S N, Yadav S K, Singh D, et al. Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model[J]. Journal of Chemical Neuroanatomy, 2016, 71:41-49.
[33] Honarvar F, Hojati V, Bakhtiari N, et al. Myelin protection by ursolic acid in cuprizone-induced demyelination in mice[J]. Iran J Pharm Res, 2019, 18(4):1978-1988.
[34] Zhang Y, Li X, Ciric B, et al. A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination[J]. Proceedings of the National Academy of Sciences, 2020, 117(16):9082-9093.
[35] Nieoczym D, Socała K, Wlaź P. Assessment of the anticonvulsant potency of ursolic acid in seizure threshold tests in mice[J]. Neurochemical Research, 2018, 43:995-1002.
[36] Taviano M F, Miceli N, Monforte M T, et al. Ursolic acid plays a role in Nepeta sibthorpii Bentham CNS depressing effects[J]. Phytotherapy Research, 2007, 21(4):382-385.
[37] Colla A R S, Oliveira Á, Pazini F L, et al. Serotonergic and noradrenergic systems are implicated in the antidepressant-like effect of ursolic acid in mice[J]. Pharmacology, Biochemistry and Behavior, 2014, 124:108-116.
[38] Ramos-Hryb A, Cunha M, Pazini F, et al. Ursolic acid affords antidepressant-like effects in mice through the activation of PKA, PKC, CAMK-II and MEK1/2[J]. Pharmacological Reports, 2017, 69(6):1240-1246
[39] Machado D G, Neis V B, Balen G O, et al. Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L in mice:Evidence for the involvement of the dopaminergic system[J]. Pharmacology Biochemistry and Behavior, 2012, 103(2):204-211.
[40] Colla A R S, Rosa J M, Cunha M P, et al. Anxiolyticlike effects of ursolic acid in mice[J]. European Journal of Pharmacology, 2015, 758:171-176.
[41] Awad R, Muhammad A, Durst T, et al. Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity[J]. Phytotherapy Research, 2009, 23:1075-1081.
[42] Khan I, Karim N, Ahmad W, et al. GABA-A receptor modulation and anticonvulsant, anxiolytic and antidepressant activities of constituents from artemisia indica linn[J]. Evidence-based Complementary and Alternative Medicine, 2016, 2016:1-12.
[43] Jeon S J, Park H J, Park S J, et al. Ursolic acid enhances pentobarbital-induced sleeping behaviors via GABAergic neurotransmission in mice[J]. European Journal of Pharmacology, 2015, 762:443-448.
[44] Tang F R, Loke W K, Yan W P, et al. Radioprotective effect of ursolic acid in radiation-induced impairment of neurogenesis, learning and memory in adolescent BALB/c mouse[J]. Physiology & Behavior, 2017, 175:37-46.
[45] Wu D M, Lu J, Zhang Y Q, et al. Ursolic acid improves domoic acid-induced cognitive deficits in mice[J]. Toxicology and Applied Pharmacology, 2013, 271(2):127-136.
[46] Lu J, Wu D M, Zheng Y L, et al. Purple sweet potato color attenuates domoic acid-induced cognitive deficits by promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice[J]. Free Radical Biology and Medicine, 2012, 52(3):646-659.
[47] Shih Y H, Chein Y C, Wang J Y, et al. Ursolic acid protects hippocampal neurons against kainate-induced excititoxity in rats[J]. Neuroscience Letters, 2004, 362(2):136-140.
[48] Wang Y J, Lu J, Wu D M, et al. Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways[J]. Neurobiology of Learning and Memory, 2011, 96(2):156-165.
[49] Lu J, Wu D M, Zheng Y L, et al. Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation[J]. Cerebral Cortex, 2010, 20(11):2540-2548.
[50] Smith S M, Vale W W. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress[J]. Dialogues in Clinical Neuroscience, 2006, 8(4):383-395.
[51] 陈磊. 脂联素介导硫化氢拮抗慢性束缚应激大鼠海马损伤及认知功能障碍[D]. 衡阳:南华大学, 2016.
[52] Mourya A, Akhtar A, Ahuja S, et al. Synergistic action of ursolic acid and metformin in experimental model of insulin resistance and related behavioral alterations[J]. European Journal of Pharmacology, 2018, 835:31-40.
[53] 朴志洙. 中药复方对D-半乳糖结合高脂饲料致认知障碍大鼠氧化应激的作用[D]. 北京:北京中医药大学, 2012.
[54] Lu J, Wu D M, Zheng Y L, et al. Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice[J]. Brain Behavior & Immunity, 2011, 25(8):1658-1667.
