Science & Technology Review >

2021 , Vol. 39 >Issue 14: 92 - 99

DOI: https://doi.org/10.3981/j.issn.1000-7857.2021.14.009

Review

Development trends of human microbiome and some suggestions

  • SHI Huilin ,
  • SUN Xuehui ,
  • XU Li ,
  • XU Ping ,
  • WANG Yue
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  • 1. Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China;
    2. School of Life Sciences Fudan University, Shanghai 200438, China

Received date: 2020-09-24

  Revised date: 2021-05-19

  Online published: 2021-09-07

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Abstract

In recent years, the advances in the new generation genomic sequencing and bioinformatics technologies have pushed forward the development of the human microbiome research. The relationships between the human microbiome and the whole life cycle health, the occurrence and the development of diseases and the function of the nutrition or the medicine have been further explored, which brings changes in the health and medical concepts. Based on a comprehensive analysis of the global human microbiome development trends, it is found that the human microbiome reference sequence analysis is still in progress, and its emphasis has shifted from the census of the composition and the distribution of the human microbiome to the analysis of the composition of the microbiome of specific populations. The analysis of the causal mechanism gradually becomes the focus of the research, meanwhile the health interventions based on the reconstruction of the human microbiome have ushered in new insights. A large number of basic researches were carried out in China on the human microbiome, and great achievements were made in specific applications, such as the fecal bacteria transplantation. However, some problems remain to be solved, such as the lack of long-term tracking and analysis of large-scale population samples, the lack of systematic research work, the insufficient independent innovation capabilities of the high-value reconstruction products, as well as some regulatory loopholes in the product development. On this basis, some feasible policy recommendations are put forward for the future development of the human microbiome in China.

Key words： human microbiome; structure and function analysis; health intervention

Cite this article

SHI Huilin , SUN Xuehui , XU Li , XU Ping , WANG Yue . Development trends of human microbiome and some suggestions[J]. Science & Technology Review, 2021 , 39(14) : 92 -99 . DOI: 10.3981/j.issn.1000-7857.2021.14.009

References

[1] Stewart C J, Ajami N J, O'Brien J L, et al. Temporal development of the gut microbiome in early childhood from the TEDDY study[J]. Nature, 2018, 562(7728):583-588.
[2] Vatanen T, Franzosa E A, Schwager R, et al. The human gut microbiome in early-onset type 1 diabetes from the TEDDY study[J]. Nature, 2018, 562(7728):589-594.
[3] Tigchelaar E F, Zhernakova A, Dekens J A M, et al. Cohort profile:LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands:Study design and baseline characteristics[J]. BMJ Open, 2015, 5(8):e006772.
[4] Goodrich J K, Waters J L, Poole A C, et al. Human genetics shape the gut microbiome[J]. Cell, 2014, 159(4):789-799.
[5] Zeevi D, Korem T, Zmora N, et al. Personalized nutrition by prediction of glycemic responses[J]. Cell, 2015, 163(5):1079-1094.
[6] Human Microbiome Project. Microbial Reference Genomes[EB/OL].[2020-08-20]. https://www.hmpdacc.org/hmp/reference_genomes/reference_genomes.php.
[7] Almeida A, Nayfach S, Boland M, et al. A unified catalog of 204938 reference genomes from the human gut microbiome[J]. Nature Biotechnology, 2021, 39(1):105-114.
[8] Mazmanian S K, Liu C H, Tzianabos A O, et al. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system[J]. Cell, 2005, 122(1):107-118.
[9] Stephen M C, Michael S, Premysl B. The interplay between the intestinal microbiota and the brain[J]. Nature Reviews Microbiology, 2012, 10:735-742.
[10] Zhang D C, Chen G, Manwani D, et al. Neutrophil ageing is regulated by the microbiome[J]. Nature, 2015, 525(7570):528-532.
[11] Zhu W, Gregory J C, Org E, et al. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk[J]. Cell, 2016, 165(1):111-124.
[12] Sampson T R, Debelius J W, Thron T, et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of parkinson's disease[J]. Cell, 2016, 167(6):1469-1480.
[13] Olson C A, Vuong H E, Yano J M, et al. The gut microbiota mediates the anti-seizure effects of the ketogenic diet[J]. Cell, 2018, 173(7):1728-1741.
[14] Zimmermann M, Zimmermann-Kogadeeva M, Wegmann R, et al. Mapping human microbiome drug metabolism by gut bacteria and their genes[J]. Nature, 2019, 570(7762):462-467
[15] Iida N, Dzutsev A, Stewart C A, et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment[J]. Science, 2013, 342(6161):967-970.
[16] Matson V, Fessler J, Bao R, et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients[J]. Science, 2018, 359(6371):104-108.
[17] Gopalakrishnan V, Spencer C N, Nezi L, et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients[J]. Science, 2018, 359(6371):97-103.
[18] Vétizou M, Pitt J M, Daillère R, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota[J]. Science, 2015, 350(6264):1079-1084.
[19] Fei N, Zhao L P. An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice[J]. The ISME Journal, 2013, 7(4):880-884.
[20] Warren J R, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis[J]. Lancet, 1983, 321(8336):1273-1275.
[21] Walter J, Armet A M, Finlay B B, et al. Establishing or exaggerating causality for the gut microbiome:Lessons from human microbiota-associated rodents[J]. Cell, 2020, 180(2):221-232.
[22] 施慧琳, 王玥, 苏燕, 等. 人类微生物组产业发展态势及建议[J]. 中国生物工程杂志, 2019, 39(6):97-103.
[23] Surawicz C M, Brandt L J, Binion D G, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections[J]. American Journal of Gastroenterology, 2013, 108(4):478-498.
[24] 张发明, 张婷. 从粪菌移植到菌群移植[J]. 科学通报, 2019, 64(3):285-290.
[25] Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing[J]. Nature, 2010, 464(7285):59-65.
[26] Li J, Jia H, Cai X, et al. An integrated catalog of reference genes in the human gut microbiome[J]. Nature Biotechnology, 2014, 32(8):834-841.
[27] Qin J J, Li Y R, Cai Z M, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes[J]. Nature, 2012, 490(7418):55-60.
[28] Zou Y, Xue W, Luo G, et al. 1520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses[J]. Nature Biotechnology, 2019, 37(2):179-185.
[29] Wu M, Liu J, Li F, et al. Antibiotic-induced dysbiosis of gut microbiota impairs corneal development in postnatal mice by affecting CCR2 negative macrophage distribution[J]. Mucosal Immunology, 2020, 13:47-63.
[30] Qi X, Yun C, Sun L, et al. Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome[J]. Nature medicine, 2019, 25(8):1225-1233.
[31] Zhao L, Zhang F, Ding X, et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes[J]. Science, 2018, 359(6380):1151-1156.
[32] Xu J, Lian F, Zhao L, et al. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula[J]. Isme Journal, 2015, 9(3):552-562.
[33] Liu R X, Hong J, Xu X Q, et al. Gut microbiome and serum metabolome alterations in obesity and after weightloss intervention[J]. Nature Medicine, 2017, 23(7):859-868.
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