There are some intrinsic connection between scientific spirit and craftsman's spirit, which can be summarized as "scientific soul and craftsman's heart". It occurs at the time when contemporary science and technology have deeply integrated while innovation of science and technology and ethics of science and technology serve as the key social links between the two kinds of spirit. During the process of cultivating "scientific soul and craftsman's heart", great importance should be attached to "responsible research and innovation" and making full use of such ideas as "unity between knowing and doing", "dominating technology by Dao" in China's outstanding traditional culture. The cultivation of "scientific soul and craftsman's heart" also needs to carry out education of scientific and technological ethics as a platform to extend the role of this cultivation, build a social atmosphere of advocating scientific and technological innovation and emphasizing ethics of science and technology, and offer the prerequisite for direction of public opinion and social governance.