The ability to perceive heat, cold and touch is the key to human adaptation to the environment. David Julius and Alden Pataptian won the 2021 Nobel Prize in Physiology or Medicine for their discovery of the TRPV1, TRPM8 ion-protein channels and PIEZO genes, unveiling the ‘mystery’ of human temperature and touch receptors. By reviewing the growth experiences, scientific research activities and research results of the two scientists in the field of human perception, the advantages and disadvantages of "pain" to the human body are discussed, and the relationship between the application of new scientific instruments and basic scientific research is investigated.
CHEN Biao
,
MENG Liuwen
,
FU Xiaohang
,
CHEN Yu
,
ZHU Zijun
,
ZHU Yuewei
,
ZOU Yuqi
,
WU Youjin
. Crack the mystery of human perception[J]. Science & Technology Review, 2022
, 40(13)
: 114
-120
.
DOI: 10.3981/j.issn.1000-7857.2022.13.012
[1] The nobel prize in physiology or medicine 2021[EB/OL]. [2021-10-20]. https://www.nobelprize.org/prizes/medicine/2021/summary.
[2] Scientific background discoveries of receptors for temperature and touch[EB/OL]. [2021-10-20]. https://www.nobelprizemedicine.org/wp-content/uploads/2021/10/Adv_info_FINAL.pdf.
[3] Ardem Patapoutian telephone interview[EB/OL]. [2021- 10-20]. https://www.nobelprize.org/prizes/medicine/2021/patapoutian/interview.
[4] David Julius telephone interview[EB/OL]. [2021-10-20]. https://www.nobelprize.org/prizes/medicine/2021/julius/interview.
[5] Cosens D J, Manning A. Abnormal electroretinogram from a drosophila mutant[J]. Nature, 1969, 224(5216): 285- 287.
[6] Montell C, Rubin G M. Molecular characterization of the drosophila TRP locus: A putative integral membrane protein required for phototransduction[J]. Neuron, 1989, 2(4): 1313-1323.
[7] The Nobel Prize in Chemistry 2003[EB/OL]. [2021-10- 20]. https://www.nobelprize.org/prizes/chemistry/2003/summary.
[8] 大卫·朱利雅斯教授首传[EB/OL]. [2021-10-20]. https://www.shawprize.org/sc/prizes-and-laureates/life-scienceand-medicine/2010/autobiography-of-david-julius.
[9] David Julius[EB/OL]. [2021-10-20]. https://www.kavliprize.org/bio/David-julius.
[10] Autobiography of Ardem Patapoutian[EB/OL]. [2021-10- 20]. https://kavliprize.org/sites/default/files/TKP 2020 Neuro autobiographies Ardem Patapoutian.pdf.
[11] 2020 Kavli Prize in neuroscience[EB/OL]. [2021-10-20]. https://kavliprize.org/prizes-and-laureates/prizes/2020-kavli-prize-neuroscience.
[12] Caterina M J, Schumacher M A, Tominaga M, et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway[J]. Nature, 1997, 389(6653): 816-824.
[13] UCLA alumnus Ardem Patapoutian wins 2021 Nobel Prize in physiology or medicine[EB/OL]. [2021-10-20]. https://newsroom.ucla.edu/releases/ardem-patapoutianucla-alumnus-nobel-prize-physiology-medicine.
[14] Coste B, Mathur J, Schmidt M, et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels[J]. Science, 2010, 330(6000): 55- 60.
[15] David Julies awards[EB/OL]. [2021-10-20]. https://en.wikipedia.org/wiki/David_Julius.
[16] Ardem Patapoutian[EB/OL]. [2021-10-20]. https://en.wikipedia.org/wiki/Ardem_Patapoutian.
[17] Nobel-Prize-medicine-physiology-temperature-touch[EB /OL]. [2021-10-20]. https://www.nytimes.com/2021/10/04/health/nobel-prize-medicine-physiology-temperature-touch.html.
[18] Liao M, Cao E, David J, et al. Structure of the Trpv1 ion channel determined by electron cryo-microscopy[J]. Nature, 2013, 504(7478): 107-112.
[19] Cao E, Liao M, Cheng Y, et al. Trpv1 structures in distinct conformations reveal activation mechanisms[J]. Nature, 2013, 504(7478): 113-118.
[20] Coste B, Xiao B, Santos J S, et al. Piezo proteins are pore-forming subunits of mechanically activated channels[J]. Nature, 2012, 483(7388): 176-181.
[21] Ge J, Li W, Zhao Q, et al. Architecture of the mammalian mechanosensitive Piezo1 channel[J]. Nature, 2015, 527(7576): 64-69.
[22] Zhao Q, Zhou H, Chi S, et al. Structure and mechanogating mechanism of the Piezo1 channel[J]. Nature, 2018, 554(7693): 487.
[23] Wang L, Zhou H, Zhang M, et al. Structure and mechanogating of the mammalian tactile channel PIEZO2[J]. Nature, 2019, 573(7773): 1-5.
[24] Jiang Y, Yang X, Jiang J, et al. Structural designs and mechanogating mechanisms of the mechanosensitive Piezo channels[J]. Trends in Biochemical Sciences, 2021, 46(6): 472-488.
