The combination of science and technology has expanded the multi-dimensional possibility of human action. In recent years, ethical events triggered by new technologies such as gene editing and artificial intelligence have pushed the ethical governance of science and technology from the background to the foreground. Based on the systematic exposition of the integration of the science and technology ethics and the emergence of China's science and technology ethics governance, this paper analyzes the reasons why the science and technology ethics governance needs practical wisdom as a practical activity and the ways how the practical wisdom guides the science and technology ethics governance. It is shown that the application of the modern science and technology requires "ethics first". The practical wisdom can deal with the conflict between "can proposition" and "should proposition" in the science and technology ethics, constantly balance the principles of the prevention and the initiative, judge the human well-being and clarify the responsibility of the science and technology ethics governance. The results show that the practical wisdom provides a specific guidance for the ethical governance of science and technology by balancing the abstract principles and the specific scenarios, grasping the ethical boundaries of the science and technology application and the scientific and technological risks. The practical wisdom is not the wisdom of a single subject, but the consensus of all the wisdom of the governance community. Therefore, we must build a scientific and technological ethics governance community.