Major infrastructure for science and technology is an important constituent of national infrastructure, a significant strength  symbol  of  the  national  science,  technology,  economy,  and  even  the  soft  power.  The  construction  of  China's  major infrastructure for science and technology started in 1960s and experienced germination, growth, development, and  rapid development  stages.  Some  facilities  have  reached  the  world's  leading  level,  generating  a  number  of  internationally  renowned achievements in science and technology, which substantially supported national strategic needs and sustained the development of science and technology. However, there are  still gaps and  shortcomings in  construction  of national major infrastructure  for science and technology, such as the lack of world-leading, original or even unique facilities, the need to strengthen the institutionalize  research  at  facilities  and  to  improve  the  international  cooperation.  China's  science  and  technology  development needs to resolve the above issues, to strengthen the top-level design and optimize the management, to initiate large international science projects so as to make greater contributions to the economic and social development, the construction of a world-leading country on science and technology with a high level of self-reliance and self-strengthening.