[1] 甄橙. 程之范医学史[M]. 北京: 北京大学医学出版社, 2023: 64-65.
[2] Jenner E. An inquiry into the causes and effects of the variolae vaccinae[M]. London: Sampson Low, 1798.
[3] Press release for the Nobel Prize in Physiology or Medicine 2023[EB/OL]. [2023-10-16]. https://www.nobelprize.org/prizes/medicine/2023/press-release.
[4] Dolgin E. The tangled history of mRNA vaccines[J]. Nature, 2021, 597(7876): 318-324.
[5] Brenner S, Jacob F, Meselson M. An unstable intermediate carrying information from genes to ribosomes for protein synthesis[J]. Nature, 1961, 190(4776): 576-581.
[6] Gros F, Hiatt H, Gilbert W, et al. Unstable ribonucleic acid revealed by pulse labelling of Escherichia coli[J]. Nature, 1961, 190(4776): 581-585.
[7] Cobb M. Who discovered messenger RNA?[J]. Current Biology, 2015, 25(13): R526-R532.
[8] Jacob F, Monod J. Genetic regulatory mechanisms in the synthesis of proteins[J]. Journal of Molecular Biology, 1961, 3(3): 318-356.
[9] Butler E T, Chamberlin M J. Bacteriophage SP6-specific RNA polymerase. I. Isolation and characterization of the enzyme[J]. Journal of Biological Chemistry, 1982, 257(10): 5772-5778.
[10] Green M R, Maniatis T, Melton D A. Human β-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei[J]. Cell, 1983, 32(3): 681-694.
[11] Krieg P A, Melton D A. Formation of the 3' end of histone mRNA by post-transcriptional processing[J]. Nature, 1984, 308(5955): 203-206.
[12] Krieg P A, Melton D A. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs [J]. Nucleic Acids Research, 1984, 12(18): 7057-7070.
[13] Krieg P A, Melton D A. In vitro RNA synthesis with SP6 RNA polymerase[J]. Methods in Enzymology, 1987, 155: 397-415.
[14] Lockard R E, Lingrel J B. The synthesis of mouse hemoglobin beta-chains in a rabbit reticulocyte cell-free system programmed with mouse reticulocyte 9S RNA[J]. Biochemical and Biophysical Research Communications, 1969, 37(2): 204-212.
[15] Lingrel J B. How I became a biochemist[J]. IUBMB Life, 2007, 59(10): 685-687.
[16] Gurdon J B, Lane C D, Woodland H R, et al. Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells[J]. Nature, 1971, 233(5316): 177-182.
[17] Wolff J A, Malone R W, Williams P, et al. Direct gene transfer into mouse muscle in vivo[J]. Science, 1990, 247(4949): 1465-1468.
[18] Jirikowski G F, Sanna P P, Maciejewski-Lenoir D, et al. Reversal of diabetes insipidus in Brattleboro rats: Intrahypothalamic injection of vasopressin mRNA[J]. Science, 1992, 255(5047): 996-998.
[19] Isaacs A, Cox R A, Rotem Z. Foreign nucleic acids as the stimulus to make interferon[J]. Lancet, 1963, 2(7299): 113-116.
[20] Karikó K, Buckstein M, Ni H P, et al. Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA[J]. Immunity, 2005, 23(2): 165-175.
[21] Karikó K, Muramatsu H, Welsh F A, et al. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability[J]. Molecular Therapy, 2008, 16(11): 1833-1840.
[22] Anderson B R, Muramatsu H, Nallagatla S R, et al. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation[J]. Nucleic Acids Research, 2010, 38(17): 5884-5892.
[23] Deamer D W. From "Banghasomes" to liposomes: A memoir of Alec Bangham, 1921-2010[J]. FASEB Journal, 2010, 24(5): 1308-1310.
[24] Bangham A. The physical chemistry of self/non-self: Jigsaws, transplants and fetuses[J]. FASEB Journal, 2009, 23(11): 3644-3646.
[25] Bangham A D, Horne R W. Action of saponin on biological cell membranes[J]. Nature, 1962, 196(4858): 952-953.
[26] Glauert A M, Dingle J, Lucy J. Action of saponin on biological cell membranes[J]. Nature, 1962, 196(4858): 953-955.
[27] Bangham A D, Horne R W. Negative staining of phospholipids and their structural modification by surfaceactive agents as observed in the electron microscope[J]. Journal of Molecular Biology, 1964, 8(5): 660-668.
[28] Sessa G, Weissmann G. Phospholipid spherules (liposomes) as a model for biological membranes[J]. Journal of Lipid Research, 1968, 9(3): 310-318.
[29] Bangham A D, Standish M M, Watkins J C. Diffusion of univalent ions across the lamellae of swollen phospholipids[J]. Journal of Molecular Biology, 1965, 13(1): 238-252.
[30] Bangham A D, Standish M M, Weissmann G. The action of steroids and streptolysin S on the permeability of phospholipid structures to cations[J]. Journal of Molecular Biology, 1965, 13(1): 253-259.
[31] Dimitriadis G J. Translation of rabbit globin mRNA introduced by liposomes into mouse lymphocytes[J]. Nature, 1978, 274(5674): 923-924.
[32] Ostro M J, Giacomoni D, Lavelle D, et al. Evidence for translation of rabbit globin mRNA after liposome-mediated insertion into a human cell line[J]. Nature, 1978, 274(5674): 921-923.
[33] Felgner P L, Gadek T R, Holm M, et al. Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84(21): 7413-7417.
[34] Malone R W, Felgner P L, Verma I M. Cationic liposome-mediated RNA transfection[J]. Proceedings of the National Academy of Sciences of the United States of America, 1989, 86(16): 6077-6081.
[35] Malone R W. mRNA transfection of cultured eukaryotic cells and embryos using cationic liposomes[J]. Focus, 1989, 11(1): 61-66.
[36] Tang D C, DeVit M, Johnston S A. Genetic immunization is a simple method for eliciting an immune response [J]. Nature, 1992, 356(6365): 152-154.
[37] Martinon F, Krishnan S, Lenzen G, et al. Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA[J]. European Journal of Immunology, 1993, 23(7): 1719-1722.
[38] Conry R M, LoBuglio A F, Wright M, et al. Characterization of a messenger RNA polynucleotide vaccine vector [J]. Cancer Research, 1995, 55(7): 1397-1400.
[39] Horejs C. From lipids to lipid nanoparticles to mRNA vaccines[J]. Nature Reviews Materials, 2021, 6(12): 1075-1076.
[40] Cullis P R, de Kruijff B. Lipid polymorphism and the functional roles of lipids in biological membranes[J]. Biochimica et Biophysica Acta, 1979, 559(4): 399-420.
[41] Hafez I M, Ansell S, Cullis P R. Tunable pH-sensitive liposomes composed of mixtures of cationic and anionic lipids[J]. Biophysical Journal, 2000, 79(3): 1438-1446.
[42] Semple S C, Klimuk S K, Harasym T O, et al. Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: Formation of novel small multilamellar vesicle structures[J]. Biochimica et Biophysica Acta, 2001, 1510(1/2): 152-166.
[43] Fenske D B, Palmer L R, Chen T, et al. Cationic poly (ethyleneglycol) lipids incorporated into pre-formed vesicles enhance binding and uptake to BHK cells[J]. Biochimica et Biophysica Acta, 2001, 1512(2): 259-272.
[44] Maurer N, Wong K F, Stark H, et al. Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes[J]. Biophysical Journal, 2001, 80(5): 2310-2326.
[45] Hafez I M, Maurer N, Cullis P R. On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids[J]. Gene Therapy, 2001, 8(15): 1188-1196.
[46] Geall A J, Verma A, Otten G R, et al. Nonviral delivery of self-amplifying RNA vaccines[J]. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(36): 14604-14609.
[47] Alberer M, Gnad-Vogt U, Hong H S, et al. Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: An open-label, non-randomised, prospective, first-in-human phase 1 clinical trial[J]. Lancet, 2017, 390(10101): 1511-1520.
[48] Feldman R A, Fuhr R, Smolenov I, et al. mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials [J]. Vaccine, 2019, 37(25): 3326-3334.
[49] Polack F P, Thomas S J, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA covid-19 vaccine[J]. The New England Journal of Medicine, 2020, 383(27): 2603-2615.
[50] Baden L R, El Sahly H M, Essink B, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine[J]. The New England Journal of Medicine, 2021, 384(5): 403-416.
[51] Nobel Prize winner Katalin Karikó was 'demoted 4 times' at her old job. How she persisted: 'You have to focus on what's next'[EB/OL]. [2023-10-16]. https://www.cnbc.com/2023/10/06/nobel-prize-winner-katalin-karik-onbeing-demoted-perseverance-.html.