Lung cancer is the most common lung malignancy and the leading cause of cancer-related death. Non platelet RNAcontaining particles (NPRCP) are a new type of regenerative particles. The aim of the study is to clarify the effects of NPRCP on lung cancer cells by observing the influence of NPRCP at different concentrations on inhibition ratio, cell surface markers, and cell cycle of A549 cells. The indicators are the cell inhibition ration after co-culture of NPRCP and A549 cells, and the cell cycle of A549 and the expression rate of CD133, CD44, CD24 and ABCG2 detected by flow cytometry. The results show inhibitory dose-response and time-dependent effect of NPRCP on lung cancer A549 cells. As the concentration of NPRCP increased, the CD44 expression rate on A549 cells decreased significantly. It suggests that NPRCP can inhibit the proliferation and CD44 expression of lung cancer A549 cells, and NPRCP may inhibit tumor proliferation and metastasis by downregulating the CD44 expression of A549 cells.
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